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Computational Fluid Dynamics-Based Blood Flow Assessment Facilitates Optimal Management of Portal Vein Stenosis After Liver Transplantation
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Computational Fluid Dynamics-Based Blood Flow Assessment Facilitates Optimal Management of Portal Vein Stenosis After Liver Transplantation
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Journal Article
Computational Fluid Dynamics-Based Blood Flow Assessment Facilitates Optimal Management of Portal Vein Stenosis After Liver Transplantation
2020
Overview
Background
Portal vein stenosis develops in 3.4–14% of split liver transplantation
1
–
3
and its early detection and treatment are essential to achieve long-term graft survival,
2
–
5
although the diagnostic capability of conventional modalities such as Doppler ultrasound and computed tomography is limited.
1
,
4
,
5
Methods
This study used computational fluid dynamics to analyze portal vein hemodynamics in the management of post-transplant portal vein stenosis. To perform computational fluid dynamics analyses, three-dimensional portal vein model was created using computed tomographic DICOM data. The inlet flow condition was set according the flow velocity measured on Doppler ultrasonography. Finally, portal vein flow was simulated on a fluid analysis software (Software Cradle, Japan).
Results
An 18-month-old girl underwent liver transplantation using a left lateral graft for biliary atresia. At the post-transplant 1-week evaluation, the computational fluid dynamics streamline analysis visualized vortices and an accelerated flow with a velocity ratio < 2 around the anastomotic site. The wall shear stress analysis revealed a high wall shear stress area within the post-anastomotic portal vein. At the post-transplant 6-month evaluation, the streamline analysis illustrated the increased vortices and worsening flow acceleration to reach the proposed diagnostic criteria (velocity ratio > 3:1).
3
,
5
The pressure analysis revealed a positive pressure gradient of 3.8 mmHg across the stenotic site. Based on the findings, the patient underwent percutaneous transhepatic portal venoplasty with balloon dilation. The post-treatment analyses confirmed the improvement of a jet flow, vortices, a high wall shear stress, and a pressure gradient.
Discussion
The computational fluid dynamics analyses are useful for prediction, early detection, and follow-up of post-transplant portal vein stenosis and would be a promising technology in post-transplant management.
Publisher
Springer US,Springer Nature B.V
Subject
Anastomosis, Surgical - adverse effects
/ Constriction, Pathologic - diagnosis
/ Constriction, Pathologic - etiology
/ Constriction, Pathologic - physiopathology
/ Diagnosis, Computer-Assisted
/ Female
/ Humans
/ Infant
/ Liver Transplantation - adverse effects
/ Medicine
/ Portal Vein - diagnostic imaging
/ Portal Vein - physiopathology
/ Surgery
/ Vortices
