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Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells
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Journal Article
Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells
2015
Overview
Epstein–Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein for infection of both B and epithelial cells, and determines EBV susceptibility of non-B cells. Here we show that neuropilin 1 (NRP1) directly interacts with EBV gB
23–431
. Either knockdown of NRP1 or pretreatment of EBV with soluble NRP1 suppresses EBV infection. Upregulation of NRP1 by overexpression or EGF treatment enhances EBV infection. However, NRP2, the homologue of NRP1, impairs EBV infection. EBV enters nasopharyngeal epithelial cells through NRP1-facilitated internalization and fusion, and through macropinocytosis and lipid raft-dependent endocytosis. NRP1 partially mediates EBV-activated EGFR/RAS/ERK signalling, and NRP1-dependent receptor tyrosine kinase (RTK) signalling promotes EBV infection. Taken together, NRP1 is identified as an EBV entry factor that cooperatively activates RTK signalling, which subsequently promotes EBV infection in nasopharyngeal epithelial cells.
Epstein–Barr virus (EBV) is involved in the development of some cancers including nasopharyngeal carcinoma. Here, the authors show that a direct interaction between the viral protein gB and a host protein, neuropilin 1, is required for EBV infection of nasopharyngeal epithelial cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Pub. Group
Subject
/ 13/1
/ 13/109
/ 13/31
/ 13/89
/ 14
/ 14/19
/ 692/699/67/1990/291/1621/1915
/ Cancer
/ Cells
/ Epithelial Cells - metabolism
/ Epithelial Cells - pathology
/ Epstein-Barr Virus Infections - metabolism
/ Epstein-Barr Virus Infections - pathology
/ Epstein-Barr Virus Infections - virology
/ Herpesvirus 4, Human - physiology
/ Humanities and Social Sciences
/ Humans
/ Kinases
/ Lymphoma
/ Nasopharyngeal Neoplasms - metabolism
/ Nasopharyngeal Neoplasms - pathology
/ Nasopharyngeal Neoplasms - virology
/ Pallets
/ Peptides
/ Science
/ Viruses
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