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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
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Journal Article
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
2014
Overview
Chronic inflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-grade inflammation induced by knockout of the
nfkb1
subunit of the transcription factor NF-κB induces premature ageing in mice. We also show that these mice have reduced regeneration in liver and gut.
nfkb1
−/−
fibroblasts exhibit aggravated cell senescence because of an enhanced autocrine and paracrine feedback through NF-κB, COX-2 and ROS, which stabilizes DNA damage. Preferential accumulation of telomere-dysfunctional senescent cells in
nfkb1
−/−
tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative potential. Frequencies of senescent cells in liver and intestinal crypts quantitatively predict mean and maximum lifespan in both short- and long-lived mice cohorts. These data indicate that systemic chronic inflammation can accelerate ageing via ROS-mediated exacerbation of telomere dysfunction and cell senescence in the absence of any other genetic or environmental factor.
Many age-related diseases are associated with chronic inflammation. Here Jurk
et al
. use a mouse model of chronic, low-grade inflammation to support a model by which such inflammation promotes a vicious cycle of oxidative stress, telomere dysfunction and cell senescence that accelerates the ageing process.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Pub. Group
Subject
/ 13/106
/ 13/51
/ 14/19
/ 14/32
/ 64
/ 64/60
/ Aging
/ Aging, Premature - immunology
/ Animals
/ Cellular Senescence - genetics
/ Cellular Senescence - immunology
/ Cyclooxygenase 2 - metabolism
/ DNA
/ Humanities and Social Sciences
/ Liver
/ Liver Regeneration - genetics
/ Liver Regeneration - immunology
/ Mice
/ NF-kappa B p50 Subunit - genetics
/ NF-kappa B p50 Subunit - immunology
/ Reactive Oxygen Species - metabolism
/ Science
/ Telomere Homeostasis - genetics
/ Telomere Homeostasis - immunology
/ Yeast
