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A prospective epidemiological study of new incident GISTs during two consecutive years in Rhône Alpes region: incidence and molecular distribution of GIST in a European region
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A prospective epidemiological study of new incident GISTs during two consecutive years in Rhône Alpes region: incidence and molecular distribution of GIST in a European region
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Journal Article
A prospective epidemiological study of new incident GISTs during two consecutive years in Rhône Alpes region: incidence and molecular distribution of GIST in a European region
2010
Overview
Background:
Preliminary data indicate that the molecular epidemiology of localised gastrointestinal stromal tumour (GIST) may be different from that of advanced GIST. We sought to investigate the molecular epidemiology of sarcomas, including GIST, in the Rhone-Alpes region in France.
Patients and methods:
A prospective and exhaustive study in the Rhone-Alpes Region in France to assess the precise incidence of primary sarcomas with systematic centralised pathological review and molecular analysis was conducted for 2 consecutive years.
Results:
Among 760 patients with a confirmed diagnosis of sarcoma, 131 (17%) had a GIST. The majority of patients had gastric primaries (61%). Mutational analysis could be performed in 106 tumour samples (74%), and 71 (67%) had exon 11 mutations.
PDGFRA
mutations were found in 16% of cases, which is twice as high as previously reported for advanced GIST.
Conclusion:
Data indicate that
PDGFRA
mutations in localised GIST may be twice as high as what was previously reported in patients with advanced disease. This finding may have important consequences for patients offered adjuvant imatinib, although most of these tumours are in the low-risk group.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Female
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Gastrointestinal Stromal Tumors - epidemiology
/ Gastrointestinal Stromal Tumors - genetics
/ Humans
/ Kinases
/ Male
/ Mutation
/ Oncology
/ Patients
/ Receptor, Platelet-Derived Growth Factor alpha - genetics
/ Sarcoma
/ Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
/ Tumors
