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A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila
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A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila
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Journal Article
A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila
2019
Overview
Sleep remains a major mystery of biology. In particular, little is known about the mechanisms that account for the drive to sleep. In an unbiased screen of more than 12,000 Drosophila lines, we identified a single gene, nemuri, that induces sleep. The NEMURI protein is an antimicrobial peptide that can be secreted ectopically to drive prolonged sleep (with resistance to arousal) and to promote survival after infection. Loss of nemuri increased arousability during daily sleep and attenuated the acute increase in sleep induced by sleep deprivation or bacterial infection. Conditions that increase sleep drive induced expression of nemuri in a small number of fly brain neurons and targeted it to the sleep-promoting, dorsal fan-shaped body. We propose that NEMURI is a bona fide sleep homeostasis factor that is particularly important under conditions of high sleep need; because these conditions include sickness, our findings provide a link between sleep and immune function.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Antiinfectives and antibacterials
/ Antimicrobial Cationic Peptides - genetics
/ Arousal
/ Bacterial Infections - immunology
/ Brain
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - immunology
/ Drosophila Proteins - genetics
/ Female
/ Fruits
/ Insects
/ Male
/ Neurons
/ Peptides
/ Proteins
/ Sleep
