Journal Article

Fibre orientation atlas guided rapid segmentation of white matter tracts

Clayden, Jonathan D., Young, Fiona, Clark, Chris A., Mancini, Laura, Aquilina, Kristian, Seunarine, Kiran K.

2024

Overview

Fibre tract delineation from diffusion magnetic resonance imaging (MRI) is a valuable clinical tool for neurosurgical planning and navigation, as well as in research neuroimaging pipelines. Several popular methods are used for this task, each with different strengths and weaknesses making them more or less suited to different contexts. For neurosurgical imaging, priorities include ease of use, computational efficiency, robustness to pathology and ability to generalise to new tracts of interest. Many existing methods use streamline tractography, which may require expert neuroimaging operators for setting parameters and delineating anatomical regions of interest, or suffer from as a lack of generalisability to clinical scans involving deforming tumours and other pathologies. More recently, data‐driven approaches including deep‐learning segmentation models and streamline clustering methods have improved reproducibility and automation, although they can require large amounts of training data and/or computationally intensive image processing at the point of application. We describe an atlas‐based direct tract mapping technique called ‘tractfinder’, utilising tract‐specific location and orientation priors. Our aim was to develop a clinically practical method avoiding streamline tractography at the point of application while utilising prior anatomical knowledge derived from only 10–20 training samples. Requiring few training samples allows emphasis to be placed on producing high quality, neuro‐anatomically accurate training data, and enables rapid adaptation to new tracts of interest. Avoiding streamline tractography at the point of application reduces computational time, false positives and vulnerabilities to pathology such as tumour deformations or oedema. Carefully filtered training streamlines and track orientation distribution mapping are used to construct tract specific orientation and spatial probability atlases in standard space. Atlases are then transformed to target subject space using affine registration and compared with the subject's voxel‐wise fibre orientation distribution data using a mathematical measure of distribution overlap, resulting in a map of the tract's likely spatial distribution. This work includes extensive performance evaluation and comparison with benchmark techniques, including streamline tractography and the deep‐learning method TractSeg, in two publicly available healthy diffusion MRI datasets (from TractoInferno and the Human Connectome Project) in addition to a clinical dataset comprising paediatric and adult brain tumour scans. Tract segmentation results display high agreement with established techniques while requiring less than 3 min on average when applied to a new subject. Results also display higher robustness than compared methods when faced with clinical scans featuring brain tumours and resections. As well as describing and evaluating a novel proposed tract delineation technique, this work continues the discussion on the challenges surrounding the white matter segmentation task, including issues of anatomical definitions and the use of quantitative segmentation comparison metrics. A rapid atlas‐based direct white matter tract segmentation technique is extensively validated in three different datasets with consistent and strong results. Improved performance and explainability in the presence of pathology is demonstrated over alternatives methods.

• Publisher: John Wiley & Sons, Inc
• Subject: Algorithms / Automation / Brain / Brain cancer / Brain mapping / Brain research / Brain tumors / Clustering / Computational efficiency / Computational neuroscience / Computing time / Datasets / Deep learning / Deformation / Delineation / diffusion MRI / diffusion‐weighted MRI / Edema / Fiber orientation / fibre tractography / Image processing / Magnetic resonance imaging / Mapping / Mathematical models / Medical imaging / Medical research / Neuroimaging / Neurosurgery / Operators (mathematics) / Pathology / Performance evaluation / Regulatory approval / Reproducibility / Robustness (mathematics) / Segmentation / Spatial distribution / Substantia alba / Tumors / white matter / white matter tract segmentation