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Integrating PET and MRI Radiomics for Staging and Prognostic Stratification in Anal Canal Cancer
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Integrating PET and MRI Radiomics for Staging and Prognostic Stratification in Anal Canal Cancer
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Journal Article
Integrating PET and MRI Radiomics for Staging and Prognostic Stratification in Anal Canal Cancer
2025
Overview
This study examined whether radiomic features extracted from PET and MRI can enhance prognostication and staging in anal squamous cell carcinoma. A PET-derived shape feature, SHAPE_Volume(vx)(log), was a strong predictor of progression-free survival, and a two-feature model incorporating a heterogeneity measure (GLZLM_SZE) further improved long-term predictive performance. Additionally, eleven PET- and MRI-derived features reliably distinguished early (stage I/II) from advanced (stage III/IV) disease. These findings support the potential of integrated PET/MRI radiomics as non-invasive biomarkers for refined staging and individualized risk stratification, offering clinically meaningful information that may assist treatment planning and patient management.
Publisher
MDPI AG,Multidisciplinary Digital Publishing Institute (MDPI)
