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Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas
by
Totsch, Stacie
, Nan, Li
, Bag, Asim K
, Bernstock, Joshua D
, McNall-Knapp, Rene
, Kang, Kyung-Don
, Madan-Swain, Avi
, Osorio, Diana S
, Farouk Sait, Sameer
, Johnston, James M
, Fiveash, John B
, Aban, Inmaculada
, Pastakia, Devang
, Palmer, Joshua D
, Martin, Allison M
, Li, Rong
, Khakoo, Yasmin
, Atkinson, T. Prescott
, Markert, James M
, Whitley, Richard J
, Gillespie, G. Yancey
, Friedman, Gregory K
, Woodling, Karina
, Kachurak, Kara
, Leonard, Jeffrey
, Schlappi, Charles
, Karajannis, Matthias A
, Abdelbaki, Mohamed S
in
Adolescent
/ Adolescents
/ Adverse events
/ Biopsy
/ Brain cancer
/ Brain Neoplasms - diagnostic imaging
/ Brain Neoplasms - pathology
/ Brain Neoplasms - radiotherapy
/ Brain Neoplasms - therapy
/ Brain tumors
/ Catheters
/ Chemotherapy
/ Child
/ Child, Preschool
/ Children
/ Clinical trials
/ Combined Modality Therapy
/ Conjunctiva
/ Drug dosages
/ Female
/ Genetic engineering
/ Glioma
/ Glioma - diagnostic imaging
/ Glioma - pathology
/ Glioma - radiotherapy
/ Glioma - therapy
/ Herpes simplex
/ Herpes viruses
/ Humans
/ Immunotherapy
/ Kaplan-Meier Estimate
/ Killer Cells, Natural
/ Kinases
/ Leukocyte Count
/ Lymphocytes
/ Male
/ Oncolysis
/ Oncolytic Virotherapy - adverse effects
/ Patients
/ Pediatrics
/ Polymerase chain reaction
/ Saliva
/ T-Lymphocytes
/ Teenagers
/ Tumor-infiltrating lymphocytes
/ Tumors
2021
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Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas
by
Totsch, Stacie
, Nan, Li
, Bag, Asim K
, Bernstock, Joshua D
, McNall-Knapp, Rene
, Kang, Kyung-Don
, Madan-Swain, Avi
, Osorio, Diana S
, Farouk Sait, Sameer
, Johnston, James M
, Fiveash, John B
, Aban, Inmaculada
, Pastakia, Devang
, Palmer, Joshua D
, Martin, Allison M
, Li, Rong
, Khakoo, Yasmin
, Atkinson, T. Prescott
, Markert, James M
, Whitley, Richard J
, Gillespie, G. Yancey
, Friedman, Gregory K
, Woodling, Karina
, Kachurak, Kara
, Leonard, Jeffrey
, Schlappi, Charles
, Karajannis, Matthias A
, Abdelbaki, Mohamed S
in
Adolescent
/ Adolescents
/ Adverse events
/ Biopsy
/ Brain cancer
/ Brain Neoplasms - diagnostic imaging
/ Brain Neoplasms - pathology
/ Brain Neoplasms - radiotherapy
/ Brain Neoplasms - therapy
/ Brain tumors
/ Catheters
/ Chemotherapy
/ Child
/ Child, Preschool
/ Children
/ Clinical trials
/ Combined Modality Therapy
/ Conjunctiva
/ Drug dosages
/ Female
/ Genetic engineering
/ Glioma
/ Glioma - diagnostic imaging
/ Glioma - pathology
/ Glioma - radiotherapy
/ Glioma - therapy
/ Herpes simplex
/ Herpes viruses
/ Humans
/ Immunotherapy
/ Kaplan-Meier Estimate
/ Killer Cells, Natural
/ Kinases
/ Leukocyte Count
/ Lymphocytes
/ Male
/ Oncolysis
/ Oncolytic Virotherapy - adverse effects
/ Patients
/ Pediatrics
/ Polymerase chain reaction
/ Saliva
/ T-Lymphocytes
/ Teenagers
/ Tumor-infiltrating lymphocytes
/ Tumors
2021
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Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas
by
Totsch, Stacie
, Nan, Li
, Bag, Asim K
, Bernstock, Joshua D
, McNall-Knapp, Rene
, Kang, Kyung-Don
, Madan-Swain, Avi
, Osorio, Diana S
, Farouk Sait, Sameer
, Johnston, James M
, Fiveash, John B
, Aban, Inmaculada
, Pastakia, Devang
, Palmer, Joshua D
, Martin, Allison M
, Li, Rong
, Khakoo, Yasmin
, Atkinson, T. Prescott
, Markert, James M
, Whitley, Richard J
, Gillespie, G. Yancey
, Friedman, Gregory K
, Woodling, Karina
, Kachurak, Kara
, Leonard, Jeffrey
, Schlappi, Charles
, Karajannis, Matthias A
, Abdelbaki, Mohamed S
in
Adolescent
/ Adolescents
/ Adverse events
/ Biopsy
/ Brain cancer
/ Brain Neoplasms - diagnostic imaging
/ Brain Neoplasms - pathology
/ Brain Neoplasms - radiotherapy
/ Brain Neoplasms - therapy
/ Brain tumors
/ Catheters
/ Chemotherapy
/ Child
/ Child, Preschool
/ Children
/ Clinical trials
/ Combined Modality Therapy
/ Conjunctiva
/ Drug dosages
/ Female
/ Genetic engineering
/ Glioma
/ Glioma - diagnostic imaging
/ Glioma - pathology
/ Glioma - radiotherapy
/ Glioma - therapy
/ Herpes simplex
/ Herpes viruses
/ Humans
/ Immunotherapy
/ Kaplan-Meier Estimate
/ Killer Cells, Natural
/ Kinases
/ Leukocyte Count
/ Lymphocytes
/ Male
/ Oncolysis
/ Oncolytic Virotherapy - adverse effects
/ Patients
/ Pediatrics
/ Polymerase chain reaction
/ Saliva
/ T-Lymphocytes
/ Teenagers
/ Tumor-infiltrating lymphocytes
/ Tumors
2021
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Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas
Journal Article
Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas
2021
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Overview
A neurotropic herpes simplex virus that was genetically inactivated to prevent replication in normal cells was injected into the brain tumors of 12 patients with tumors that had progressed during previous treatment. Eleven patients had some radiographic or clinical responses, with inflammation detected in some PET scans. The median survival was 12.2 months, and 4 of 11 patients were still alive 18 months after treatment.
Publisher
Massachusetts Medical Society
Subject
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