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Herbal medicine in women undergoing in vitro fertilization/ intracytoplasmic sperm injection: A systematic review and meta-analysis
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Herbal medicine in women undergoing in vitro fertilization/ intracytoplasmic sperm injection: A systematic review and meta-analysis
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Journal Article
Herbal medicine in women undergoing in vitro fertilization/ intracytoplasmic sperm injection: A systematic review and meta-analysis
2020
Overview
•Combination of in vitro fertilization (IVF) and herbal medicine (HM) has widely used.•HM is more likely to increase live birth rate (LBR) and clinical pregnancy rate (CPR) than not receiving adjunctive treatment.•The CPR in HM treatment group was also improved when compared with that of the placebo group.•Given the high risk of bias of the included studies, however, we made a careful conclusion calling for further investigation.
A combination of in vitro fertilization (IVF) and herbal medicine (HM) has been widely used in Asian countries. We conducted a systematic review of randomized controlled trials (RCTs) that evaluated the effects of HM as an adjunct to IVF and reported the pregnancy outcomes, including the live birth rate (LBR) and clinical pregnancy rate (CPR). HM was consistently more likely to increase the LBR (RR 1.34, 95 % CI 1.05–1.72) and CPR (RR 1.38, 95 % CI 1.29–1.49) than those not receiving adjunctive treatment. The CPR in the HM treatment group was also improved compared to the placebo group (RR 1.85, 95 % CI 1.42–2.42). The adverse events were not significantly different between the HM and control groups. These findings indicate that HM may have beneficial effects on pregnancy outcomes in females undergoing IVF. Large-scale, long-term RCTs with robust methodological inputs are needed to clarify the role of HM.
Publisher
Elsevier Ltd,Elsevier Limited
Subject
