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Neurotrophins as Potential Biomarkers for Active Disease and Poor Outcome in Pediatric Acute Lymphoblastic Leukemia

by Marques, Rebeca Ferreira , de Andrade, Karine Pereira , da Cunha Jaeger, Mariane , Michaelsen, Gustavo Lovatto , Brunetto, André Tesainer , Land, Marcelo , Sinigaglia, Marialva , Loss, Jiseh Fagundes , Benincasa, Daniela Elaine Roth , de Farias, Caroline Brunetto , Roesler, Rafael , Dutra, Lívia Fratini , Portich, Júlia Plentz , Gregianin, Lauro José

in Acute lymphoblastic leukemia / Acute lymphocytic leukemia / Apoptosis / B cells / Biological markers / Biomarkers / Bone marrow / Brain-derived neurotrophic factor / Brazil / Cancer / Cell culture / Cell growth / Cell survival / Childhood / Datasets / Development and progression / Diagnosis / Diseases / Enzymes / Ethylenediaminetetraacetic acid / Gene expression / Growth factors / Kinases / Leukemia / Lymphocytes T / Medical prognosis / Nerve growth factor / Nervous system / Northwest Territories / Oncology, Experimental / Pediatrics / Signal transduction / Software / Survival analysis / Tumor microenvironment / Tumors

2025

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Neurotrophins as Potential Biomarkers for Active Disease and Poor Outcome in Pediatric Acute Lymphoblastic Leukemia

2025

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Neurotrophins as Potential Biomarkers for Active Disease and Poor Outcome in Pediatric Acute Lymphoblastic Leukemia

2025

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Journal Article

Neurotrophins as Potential Biomarkers for Active Disease and Poor Outcome in Pediatric Acute Lymphoblastic Leukemia

Marques, Rebeca Ferreira,

de Andrade, Karine Pereira,

da Cunha Jaeger, Mariane,

Michaelsen, Gustavo Lovatto,

Brunetto, André Tesainer,

Land, Marcelo,

Sinigaglia, Marialva,

Loss, Jiseh Fagundes,

Benincasa, Daniela Elaine Roth,

de Farias, Caroline Brunetto,

Roesler, Rafael,

Dutra, Lívia Fratini,

Portich, Júlia Plentz,

Gregianin, Lauro José

2025

Overview

Background: Neurotrophins (NTs) are pivotal growth factors in cellular development and survival. Their precise implications in Acute Lymphoblastic Leukemia (ALL) remain unclear. Methods: Pediatric ALL samples (2011–2021) were analyzed from a Southern Brazil cohort. Neurotrophin levels were quantified via ELISA, with survival analysis using Kaplan–Meier curves. Gene expression data were sourced from public genomic repositories and analyzed with R software version 4.0.5. Results: At diagnosis, pro-BDNF, BDNF, and NGF levels were significantly lower than in healthy controls. Reduced pro-BDNF correlated with unfavorable outcomes. NGF and sortilin were highly expressed in healthy samples, while BDNF and p75NTR were predominant in T-ALL and B-ALL, respectively. Conclusions: Neurotrophins show significant alterations in the tumor microenvironment of pediatric ALL. Further studies are needed to elucidate their precise role and prognostic potential.

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Publisher

MDPI AG,MDPI

Subject

Acute lymphoblastic leukemia

/ Acute lymphocytic leukemia

/ B cells