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Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
by
Major, Pierre P
, Bahary, Jean-Paul
, Pisansky, Thomas M
, Balogh, Alexander G
, Souhami, Luis
, Zietman, Anthony L
, Lawton, Colleen A.F
, Heney, Niall M
, Dignam, James J
, Grignon, David J
, Lovett, Richard D
, Kerlin, Kevin J
, Pugh, Stephanie L
, Lukka, Himanshu R
, Sandler, Howard M
, Zeitzer, Kenneth L
, Shipley, William U
, Seiferheld, Wendy
, Sartor, Oliver
, Rosenthal, Seth A
, Feng, Felix Y
, Patel, Maltibehn P
in
Aged
/ Aged, 80 and over
/ Androgen Antagonists - adverse effects
/ Androgen Antagonists - therapeutic use
/ Anilides - adverse effects
/ Anilides - therapeutic use
/ Cancer surgery
/ Cancer therapies
/ Combined Modality Therapy
/ Death
/ Double-Blind Method
/ Follow-Up Studies
/ Gynecomastia
/ Gynecomastia - chemically induced
/ Humans
/ Incidence
/ Kaplan-Meier Estimate
/ Male
/ Metastases
/ Middle Aged
/ Neoplasm Metastasis
/ Neoplasm Recurrence, Local - drug therapy
/ Neoplasm Recurrence, Local - mortality
/ Neoplasm Recurrence, Local - radiotherapy
/ Neoplasm Staging
/ Nitriles - adverse effects
/ Nitriles - therapeutic use
/ Oncology
/ Prostate cancer
/ Prostate-specific antigen
/ Prostatectomy
/ Prostatic Neoplasms - drug therapy
/ Prostatic Neoplasms - mortality
/ Prostatic Neoplasms - radiotherapy
/ Prostatic Neoplasms - surgery
/ Radiation therapy
/ Radiotherapy - adverse effects
/ Survival
/ Survival Rate
/ Tablets
/ Tosyl Compounds - adverse effects
/ Tosyl Compounds - therapeutic use
/ Urological surgery
2017
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Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
by
Major, Pierre P
, Bahary, Jean-Paul
, Pisansky, Thomas M
, Balogh, Alexander G
, Souhami, Luis
, Zietman, Anthony L
, Lawton, Colleen A.F
, Heney, Niall M
, Dignam, James J
, Grignon, David J
, Lovett, Richard D
, Kerlin, Kevin J
, Pugh, Stephanie L
, Lukka, Himanshu R
, Sandler, Howard M
, Zeitzer, Kenneth L
, Shipley, William U
, Seiferheld, Wendy
, Sartor, Oliver
, Rosenthal, Seth A
, Feng, Felix Y
, Patel, Maltibehn P
in
Aged
/ Aged, 80 and over
/ Androgen Antagonists - adverse effects
/ Androgen Antagonists - therapeutic use
/ Anilides - adverse effects
/ Anilides - therapeutic use
/ Cancer surgery
/ Cancer therapies
/ Combined Modality Therapy
/ Death
/ Double-Blind Method
/ Follow-Up Studies
/ Gynecomastia
/ Gynecomastia - chemically induced
/ Humans
/ Incidence
/ Kaplan-Meier Estimate
/ Male
/ Metastases
/ Middle Aged
/ Neoplasm Metastasis
/ Neoplasm Recurrence, Local - drug therapy
/ Neoplasm Recurrence, Local - mortality
/ Neoplasm Recurrence, Local - radiotherapy
/ Neoplasm Staging
/ Nitriles - adverse effects
/ Nitriles - therapeutic use
/ Oncology
/ Prostate cancer
/ Prostate-specific antigen
/ Prostatectomy
/ Prostatic Neoplasms - drug therapy
/ Prostatic Neoplasms - mortality
/ Prostatic Neoplasms - radiotherapy
/ Prostatic Neoplasms - surgery
/ Radiation therapy
/ Radiotherapy - adverse effects
/ Survival
/ Survival Rate
/ Tablets
/ Tosyl Compounds - adverse effects
/ Tosyl Compounds - therapeutic use
/ Urological surgery
2017
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Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
by
Major, Pierre P
, Bahary, Jean-Paul
, Pisansky, Thomas M
, Balogh, Alexander G
, Souhami, Luis
, Zietman, Anthony L
, Lawton, Colleen A.F
, Heney, Niall M
, Dignam, James J
, Grignon, David J
, Lovett, Richard D
, Kerlin, Kevin J
, Pugh, Stephanie L
, Lukka, Himanshu R
, Sandler, Howard M
, Zeitzer, Kenneth L
, Shipley, William U
, Seiferheld, Wendy
, Sartor, Oliver
, Rosenthal, Seth A
, Feng, Felix Y
, Patel, Maltibehn P
in
Aged
/ Aged, 80 and over
/ Androgen Antagonists - adverse effects
/ Androgen Antagonists - therapeutic use
/ Anilides - adverse effects
/ Anilides - therapeutic use
/ Cancer surgery
/ Cancer therapies
/ Combined Modality Therapy
/ Death
/ Double-Blind Method
/ Follow-Up Studies
/ Gynecomastia
/ Gynecomastia - chemically induced
/ Humans
/ Incidence
/ Kaplan-Meier Estimate
/ Male
/ Metastases
/ Middle Aged
/ Neoplasm Metastasis
/ Neoplasm Recurrence, Local - drug therapy
/ Neoplasm Recurrence, Local - mortality
/ Neoplasm Recurrence, Local - radiotherapy
/ Neoplasm Staging
/ Nitriles - adverse effects
/ Nitriles - therapeutic use
/ Oncology
/ Prostate cancer
/ Prostate-specific antigen
/ Prostatectomy
/ Prostatic Neoplasms - drug therapy
/ Prostatic Neoplasms - mortality
/ Prostatic Neoplasms - radiotherapy
/ Prostatic Neoplasms - surgery
/ Radiation therapy
/ Radiotherapy - adverse effects
/ Survival
/ Survival Rate
/ Tablets
/ Tosyl Compounds - adverse effects
/ Tosyl Compounds - therapeutic use
/ Urological surgery
2017
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Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
Journal Article
Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
2017
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Overview
With a median follow-up of 13 years, a randomized comparison of radiotherapy with or without antiandrogen therapy in patients with a rising PSA level after prostatectomy showed that 2 years of antiandrogen therapy resulted in a significantly higher overall survival rate.
Patients with localized prostatic cancer are often treated with radical prostatectomy. More than 30% of such patients will subsequently have recurrence. This recurrence manifests first as a rising serum level of prostate-specific antigen (PSA),
1
–
3
termed biochemical recurrence. Large, retrospective studies suggest that salvage radiation therapy after biochemical recurrence may be associated with long-term freedom from cancer recurrence.
4
,
5
However, 50% of the patients who are treated with salvage radiation therapy will have further disease progression, particularly when there are aggressive disease features.
4
–
7
The combination of radiation therapy and either androgen-deprivation therapy or antiandrogen therapy prolongs survival among some . . .
Publisher
Massachusetts Medical Society
Subject
/ Androgen Antagonists - adverse effects
/ Androgen Antagonists - therapeutic use
/ Death
/ Gynecomastia - chemically induced
/ Humans
/ Male
/ Neoplasm Recurrence, Local - drug therapy
/ Neoplasm Recurrence, Local - mortality
/ Neoplasm Recurrence, Local - radiotherapy
/ Oncology
/ Prostatic Neoplasms - drug therapy
/ Prostatic Neoplasms - mortality
/ Prostatic Neoplasms - radiotherapy
/ Prostatic Neoplasms - surgery
/ Radiotherapy - adverse effects
/ Survival
/ Tablets
/ Tosyl Compounds - adverse effects
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