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Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
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Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
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Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
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Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
Journal Article

Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer

2017
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Overview
With a median follow-up of 13 years, a randomized comparison of radiotherapy with or without antiandrogen therapy in patients with a rising PSA level after prostatectomy showed that 2 years of antiandrogen therapy resulted in a significantly higher overall survival rate. Patients with localized prostatic cancer are often treated with radical prostatectomy. More than 30% of such patients will subsequently have recurrence. This recurrence manifests first as a rising serum level of prostate-specific antigen (PSA), 1 – 3 termed biochemical recurrence. Large, retrospective studies suggest that salvage radiation therapy after biochemical recurrence may be associated with long-term freedom from cancer recurrence. 4 , 5 However, 50% of the patients who are treated with salvage radiation therapy will have further disease progression, particularly when there are aggressive disease features. 4 – 7 The combination of radiation therapy and either androgen-deprivation therapy or antiandrogen therapy prolongs survival among some . . .