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Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)
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Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)
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Journal Article
Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)
2026
Overview
Platelets, while essential for hemostasis, have been recognized as critical mediators in cancer metastasis. The crosstalk between platelets and circulating tumor cells (CTCs) constitutes a key driver of metastasis, emerging as a focal point in oncology research. Elucidating the underlying mechanisms provides novel insights into tumor dissemination. The present review systematically traces the evolution of platelet‑CTC crosstalk, from receptor‑mediated adhesion to bidirectional molecular exchange, and its implications for metastatic progression. Additionally, the diagnostic significance of platelet‑CTC complexes as potential biomarkers for cancer detection and prognosis is highlighted. Finally, promising therapeutic strategies targeting the platelet‑CTC crosstalk are discussed. By integrating current knowledge, it was demonstrated that targeting platelet‑CTC crosstalk holds potential for improving cancer diagnosis and therapy, while also identifying avenues for future translational research.
Publisher
Spandidos Publications,Spandidos Publications UK Ltd
Subject
/ Biomarkers, Tumor - metabolism
/ Blood Platelets - drug effects
/ Blood Platelets - metabolism
/ Cancer
/ Cell Communication - drug effects
/ Cells
/ Humans
/ Neoplastic Cells, Circulating - drug effects
/ Neoplastic Cells, Circulating - metabolism
/ Neoplastic Cells, Circulating - pathology
/ Tumors
