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Effects of ZNF804A on auditory P300 response in schizophrenia
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Effects of ZNF804A on auditory P300 response in schizophrenia
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Journal Article
Effects of ZNF804A on auditory P300 response in schizophrenia
2014
Overview
The common variant rs1344706 within the zinc-finger protein gene
ZNF804A
has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies. Although associated with a pattern of altered neural connectivity, evidence that increased risk is mediated by an effect on cognitive deficits associated with the disorder has been equivocal. This study investigated whether the same
ZNF804A
risk allele was associated with variation in the P300 auditory-evoked response, a cognitively relevant putative endophenotype for SZ. We compared P300 responses in carriers and noncarriers of the
ZNF804A
risk allele genotype groups in Irish patients and controls (
n
=97). P300 response was observed to vary according to genotype in this sample, such that risk allele carriers showed relatively higher P300 response compared with noncarriers. This finding accords with behavioural data reported by our group and others. It is also consistent with the idea that
ZNF804A
may have an impact on cortical efficiency, reflected in the higher levels of activations required to achieve comparable behavioural accuracy on the task used.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Event-Related Potentials, P300 - genetics
/ Event-Related Potentials, P300 - physiology
/ Evoked Potentials, Auditory - genetics
/ Evoked Potentials, Auditory - physiology
/ Female
/ Genotype
/ Humans
/ Kruppel-Like Transcription Factors - genetics
/ Male
/ Medicine
/ Original
