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Cefiderocol: the Trojan horse has arrived but will Troy fall?
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Journal Article
Cefiderocol: the Trojan horse has arrived but will Troy fall?
2021
Overview
Since other similar trials have not enrolled patients infected with carbapenem-resistant A baumannii, it seems unfair to compare cefiderocol's high mortality numbers with those of trials with newer β-lactam–β-lactamase inhibitors.7,8 The small number of patients infected with carbapenem-resistant A baumannii in APEKS-NP (ie, 31 patients) precludes this study's ability to shed any further insight into cefiderocol's efficacy for these challenging pathogens. [...]although trials comparing cefiderocol with worthy comparator regimens for MBL-producing Enterobacterales have not been done, there were no concerning clinical signals when cefiderocol was used in CREDIBLE-CR for such infections,2 including infections outside the urinary tract. [...]an important gap in coverage with currently available novel antibiotics is options for S maltophilia, particularly as intolerance to co-trimoxazole (trimethoprim–sulfamethoxazole) is common and the efficacy of other drugs has not been well established.
