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Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer
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Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer
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Journal Article
Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer
2021
Overview
Studies that examined an association between CD8
+
T and prognosis in gastric cancer are inconsistent, and a distinct population of CXCR5
+
CD8
+
T associated with better overall survival has been reported among various malignancies. Here, we show that the abundance of intratumoral CXCR5
+
CD8
+
T cells is associated with better overall survival in patients with gastric cancer. Patients with TNM II + III gastric cancer with higher intratumoral CXCR5
+
CD8
+
T cell infiltration are more likely to benefit from adjuvant chemotherapy. Microsatellite-unstable and Epstein–Barr virus positive tumors are enriched with CXCR5
+
CD8
+
T cells. Gastric cancer infiltrating CXCR5
+
CD8
+
T cells represent a specific subtype of stem-like CD8
+
T with effector memory feature. Identification of the clinical significance and phenotype of gastric cancer infiltrating CXCR5
+
CD8
+
T provides a roadmap for patient stratification and trials of targeted therapies.
The prognostic value of tumor infiltrating lymphocytes in gastric cancer remains controversial. Here the authors show a consistent association between higher density of intratumoral CXCR5+CD8+ T cells and longer overall survival in four different cohorts of patients with gastric cancer.
