Asset Details
Do you wish to reserve the book?
An extracellular vesicle epitope profile is associated with acute myocardial infarction
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
An extracellular vesicle epitope profile is associated with acute myocardial infarction
Do you wish to request the book?
An extracellular vesicle epitope profile is associated with acute myocardial infarction
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
An extracellular vesicle epitope profile is associated with acute myocardial infarction
2020
Overview
The current standard biomarker for myocardial infarction (MI) is high‐sensitive troponin. Although powerful in clinical setting, search for new markers is warranted as early diagnosis of MI is associated with improved outcomes. Extracellular vesicles (EVs) attracted considerable interest as new blood biomarkers. A training cohort used for diagnostic modelling included 30 patients with STEMI, 38 with stable angina (SA) and 30 matched‐controls. Extracellular vesicle concentration was assessed by nanoparticle tracking analysis. Extracellular vesicle surface‐epitopes were measured by flow cytometry. Diagnostic models were developed using machine learning algorithms and validated on an independent cohort of 80 patients. Serum EV concentration from STEMI patients was increased as compared to controls and SA. EV levels of CD62P, CD42a, CD41b, CD31 and CD40 increased in STEMI, and to a lesser extent in SA patients. An aggregate marker including EV concentration and CD62P/CD42a levels achieved non‐inferiority to troponin, discriminating STEMI from controls (AUC = 0.969). A random forest model based on EV biomarkers discriminated the two groups with 100% accuracy. EV markers and RF model confirmed high diagnostic performance at validation. In conclusion, patients with acute MI or SA exhibit characteristic EV biomarker profiles. EV biomarkers hold great potential as early markers for the management of patients with MI.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
Acute Coronary Syndrome - blood
/ Acute Coronary Syndrome - metabolism
/ Acute Coronary Syndrome - pathology
/ Aged
/ Angina
/ Epitopes
/ Extracellular Vesicles - genetics
/ Female
/ Humans
/ Ischemia
/ Male
/ Original
/ Percutaneous Coronary Intervention
/ Platelet Endothelial Cell Adhesion Molecule-1 - blood
/ Platelet Glycoprotein GPIb-IX Complex - genetics
/ ST Elevation Myocardial Infarction - blood
/ ST Elevation Myocardial Infarction - genetics
/ ST Elevation Myocardial Infarction - pathology
/ ST‐segment elevation myocardial infarction
/ Troponin
/ Values
