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Role and Regulation of the RECQL4 Family during Genomic Integrity Maintenance
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Role and Regulation of the RECQL4 Family during Genomic Integrity Maintenance
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Role and Regulation of the RECQL4 Family during Genomic Integrity Maintenance
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Journal Article
Role and Regulation of the RECQL4 Family during Genomic Integrity Maintenance
2021
Overview
RECQL4 is a member of the evolutionarily conserved RecQ family of 3’ to 5’ DNA helicases. RECQL4 is critical for maintaining genomic stability through its functions in DNA repair, recombination, and replication. Unlike many DNA repair proteins, RECQL4 has unique functions in many of the central DNA repair pathways such as replication, telomere, double-strand break repair, base excision repair, mitochondrial maintenance, nucleotide excision repair, and crosslink repair. Consistent with these diverse roles, mutations in RECQL4 are associated with three distinct genetic diseases, which are characterized by developmental defects and/or cancer predisposition. In this review, we provide an overview of the roles and regulation of RECQL4 during maintenance of genome homeostasis.
