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BCG Revaccination for the Prevention of Mycobacterium tuberculosis Infection

by Dunne, Michael W. , Fairlie, Lee , Hellström, Elizabeth , Middelkoop, Keren , Gela, Anele , Luabeya Kany Kany, Angelique , Scriba, Thomas J. , Nemes, Elisa , Cinar, Amy , Kaufman, David , Nair, Gonasagrie , Naidoo, Kogieleum , Frahm, Nicole , Hatherill, Mark , Mogg, Robin , Schmidt, Alexander C.

in Adolescent / Adolescents / Age groups / Bacillus Calmette-Guerin vaccine / BCG / BCG Vaccine - administration & dosage / BCG Vaccine - adverse effects / BCG Vaccine - immunology / CD4 antigen / Child / Cytokines / Disease prevention / Double-Blind Method / Female / Follow-Up Studies / Global Health / HIV / Human immunodeficiency virus / Humans / Immunization, Secondary - adverse effects / Immunization, Secondary - methods / Immunogenicity / Incidence / Infections / Infectious Disease / Infectious Disease General / Injection Site Reaction - epidemiology / Injection Site Reaction - etiology / Intention to Treat Analysis / Interferon / Interferon-gamma Release Tests / Lymphocytes T / Male / Mycobacterium tuberculosis / Mycobacterium tuberculosis - immunology / Placebos / South Africa - epidemiology / T-Lymphocytes, Helper-Inducer - immunology / Teenagers / Treatment Outcome / Tuberculosis / Tuberculosis - blood / Tuberculosis - diagnosis / Tuberculosis - immunology / Tuberculosis - prevention & control / Vaccine Efficacy / Vaccines / γ-Interferon

2025

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2025

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2025

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Journal Article

BCG Revaccination for the Prevention of Mycobacterium tuberculosis Infection

Dunne, Michael W.,

Fairlie, Lee,

Hellström, Elizabeth,

Middelkoop, Keren,

Gela, Anele,

Luabeya Kany Kany, Angelique,

Scriba, Thomas J.,

Nemes, Elisa,

Cinar, Amy,

Kaufman, David,

Nair, Gonasagrie,

Naidoo, Kogieleum,

Frahm, Nicole,

Hatherill, Mark,

Mogg, Robin,

Schmidt, Alexander C.

2025

Overview

Mycobacterium tuberculosis continues to cause substantial illness globally. In this phase 2b randomized trial, BCG revaccination did not prevent sustained M. tuberculosis infection in IGRA-negative, HIV-negative adolescents.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adolescents

/ Age groups

/ Bacillus Calmette-Guerin vaccine

/ BCG

/ BCG Vaccine - administration & dosage

/ BCG Vaccine - adverse effects