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KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down‐regulating SERTAD4
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KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down‐regulating SERTAD4
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Journal Article
KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down‐regulating SERTAD4
2024
Overview
This study explores and verifies potential molecular targets through which KRAS mutations regulate the colonization of Fusobacterium nucleatum (FN) in colorectal cancer (CRC). This study combined multiple bioinformatics methods and biological assays. Through The Cancer Genome Atlas, Gene Expression Omnibus, Human Protein Atlas, immunohistochemistry, and co‐culture assays, we further confirmed the differential expression of SERTAD4 in CRC. We delved deeper into examining how expression of SERTAD4 is linked with immune cell infiltration and the enrichment of potential pathways. Lastly, through bacterial phenotypic assays, we validated the function of SERTAD4. As a molecule associated with KRAS mutations and FN infection, the expression levels of SERTAD4 were downregulated in CRC. The diagnostic efficacy of SERTAD4 for CRC is not inferior to that of CEA. Low expression of SERTAD4 is associated with poorer overall survival in CRC. Correlation analysis found that increased expression of SERTAD4 is associated with various immune cell infiltrations and immune checkpoint genes. Finally, bacterial adhesion and invasion assays verify that SERTAD4 inhibits the adhesion and invasion abilities of FN in CRC. This study demonstrates that SERTAD4 exerts a protective role in CRC by inhibiting the colonization of FN.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ Cancer
/ Colorectal Neoplasms - genetics
/ Colorectal Neoplasms - microbiology
/ Colorectal Neoplasms - pathology
/ Fusobacterium Infections - complications
/ Fusobacterium Infections - genetics
/ Fusobacterium Infections - microbiology
/ Fusobacterium nucleatum - genetics
/ Fusobacterium nucleatum - pathogenicity
/ Gene Expression Regulation, Neoplastic
/ Genes
/ Humans
/ KRAS
/ Mutation
/ Original
/ Proteins
