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Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women

by Matovu Kiweewa, Flavia , Kiwanuka, Noah , Selepe, Pearl , Kotze, Philip , Gill, Katherine , Zwane, Zwelethu , Batting, Joanne , Naicker, Vimla , Kigozi, Godfrey , Mansoor, Leila E. , Ahmed, Khatija , Baeten, Jared M. , Nair, Gonasagrie , Harkoo, Ishana , Naidoo, Megeshinee , Malahleha, Moelo , Lebina, Limakatso , Zhao, Yang , Naidoo, Logashvari , Kintu, Alexander , Manentsa, Mmatsie , Panchia, Ravindre , Ebrahimi, Ramin , Singh, Yashna , Moodley, Dhayendre , Abdool Karim, Quarraisha , Potloane, Disebo , Spooner, Elizabeth , Carter, Christoph C. , Ndlovu, Nkosiphile , Palanee-Phillips, Thesla , Pillay, Saresha , Ward, Amy M. , Jaggernath, Manjeetha , Singh, Nishanta , Bekker, Linda-Gail , Louw, Cheryl E. , Das, Moupali , Deaton, Chris , Brumskine, William

in Accountability / Adenine - administration & dosage / Adenine - adverse effects / Adenine - analogs & derivatives / Administration, Oral / Adolescent / Adult / AIDS / Anti-HIV Agents - administration & dosage / Anti-HIV Agents - adverse effects / Anti-HIV Agents - therapeutic use / Antibodies / Antigens / Antiretroviral drugs / Cisgender / Clinical Medicine / Clinical Medicine General / Consent / Counseling / Design / Disease prevention / Double-Blind Method / Drug Administration Schedule / Emtricitabine / Emtricitabine - administration & dosage / Emtricitabine - adverse effects / Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination - administration & dosage / Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination - adverse effects / FDA approval / Female / Girls / Global Health / HIV / HIV Infections - epidemiology / HIV Infections - prevention & control / Human immunodeficiency virus / Humans / Incidence / Infections / Infectious Disease / Infectious Disease General / Injection / Injection Site Reaction - epidemiology / Injections, Subcutaneous - adverse effects / Laboratories / Medical tests / Medication Adherence - statistics & numerical data / Outpatient-Based Clinical Medicine / Placebos / Pre-Exposure Prophylaxis - methods / Pre-Exposure Prophylaxis - statistics & numerical data / Public Health / Public Health General / South Africa - epidemiology / Tenofovir / Tenofovir - administration & dosage / Tenofovir - adverse effects / Uganda - epidemiology / Viral Infections / Young Adult

2024

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2024

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2024

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Journal Article

Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women

Matovu Kiweewa, Flavia,

Kiwanuka, Noah,

Selepe, Pearl,

Kotze, Philip,

Gill, Katherine,

Zwane, Zwelethu,

Batting, Joanne,

Naicker, Vimla,

Kigozi, Godfrey,

Mansoor, Leila E.,

Ahmed, Khatija,

Baeten, Jared M.,

Nair, Gonasagrie,

Harkoo, Ishana,

Naidoo, Megeshinee,

Malahleha, Moelo,

Lebina, Limakatso,

Zhao, Yang,

Naidoo, Logashvari,

Kintu, Alexander,

Manentsa, Mmatsie,

Panchia, Ravindre,

Ebrahimi, Ramin,

Singh, Yashna,

Moodley, Dhayendre,

Abdool Karim, Quarraisha,

Potloane, Disebo,

Spooner, Elizabeth,

Carter, Christoph C.,

Ndlovu, Nkosiphile,

Palanee-Phillips, Thesla,

Pillay, Saresha,

Ward, Amy M.,

Jaggernath, Manjeetha,

Singh, Nishanta,

Bekker, Linda-Gail,

Louw, Cheryl E.,

Das, Moupali,

Deaton, Chris,

Brumskine, William

2024

Overview

In this randomized, controlled trial involving women in South Africa and Uganda, twice-yearly subcutaneous lenacapavir was superior to daily oral emtricitabine–tenofovir disoproxil fumarate in preventing HIV infection.

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Publisher

Massachusetts Medical Society

Subject

Accountability

/ Adenine - administration & dosage

/ Adenine - adverse effects

/ Adenine - analogs & derivatives

/ Administration, Oral

/ Adolescent

/ Adult