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Nosocomial Mycobacterium bovis–Bacille Calmette-Guérin Infections Due to Contamination of Chemotherapeutics: Case Finding and Route of Transmission

by Man, Peter de , Vos, Margreet C. , Deutekom, Henk van , de Haas, Petra E. W. , Yntema, J. L. , Vulto, Arnold G. , Verbrugh, Henri A. , Hartwig, Nico G. , Messemaker, Marja , Soolingen, Dick van , Renders, Nicole H. M. , Kolk, Arend H. J.

in Adolescent / Adult / Antineoplastic Agents - therapeutic use / Bacillus calmette guerin vaccine / Bacteria / BCG Vaccine - administration & dosage / Biological and medical sciences / Chemotherapy / Child / Child, Preschool / Cross Infection - immunology / Cross Infection - microbiology / Drug Contamination / Female / Fundamental and applied biological sciences. Psychology / Humans / Immunocompromised Host - drug effects / Immunocompromised Host - immunology / Infections / Infectious diseases / Male / Medical sciences / Microbiology / Mycobacterium bovis / Mycobacterium bovis - growth & development / Mycobacterium Infections - immunology / Mycobacterium Infections - microbiology / Mycobacterium tuberculosis / Pharmacies / Polymerase chain reaction / Urinary Bladder Neoplasms - drug therapy / Vaccination

2003

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Nosocomial Mycobacterium bovis–Bacille Calmette-Guérin Infections Due to Contamination of Chemotherapeutics: Case Finding and Route of Transmission

2003

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Nosocomial Mycobacterium bovis–Bacille Calmette-Guérin Infections Due to Contamination of Chemotherapeutics: Case Finding and Route of Transmission

2003

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Journal Article

Nosocomial Mycobacterium bovis–Bacille Calmette-Guérin Infections Due to Contamination of Chemotherapeutics: Case Finding and Route of Transmission

Man, Peter de,

Vos, Margreet C.,

Deutekom, Henk van,

de Haas, Petra E. W.,

Yntema, J. L.,

Vulto, Arnold G.,

Verbrugh, Henri A.,

Hartwig, Nico G.,

Messemaker, Marja,

Soolingen, Dick van,

Renders, Nicole H. M.,

Kolk, Arend H. J.

2003

Overview

We studied nosocomial infections due to Mycobacterium bovis bacille Calmette-Guérin (BCG) Onco-TICE bacteria, transmitted by contamination of medication prepared in BCG Onco-TICE–contaminated hoods in the pharmacy, in 5 immunocompromised patients at 3 hospitals. The BCG strains cultured from the patients had the same DNA profile as the BCG Onco-TICE strain used for bladder instillation. To prevent these infections, a change from open to closed preparation was made; strictly separated preparation in time of BCG Onco-TICE instillation and chemotherapy was enforced, the biological safety cabinet was disinfected between preparations, and gloves were changed between preparations

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Publisher

The University of Chicago Press,University of Chicago Press,Oxford University Press

Subject

Adolescent

/ Adult

/ Antineoplastic Agents - therapeutic use

/ Bacillus calmette guerin vaccine

/ Bacteria

/ BCG Vaccine - administration & dosage

/ Biological and medical sciences