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A ultra-stable point of care nanozyme-based kit for cTnI detection in human serum
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A ultra-stable point of care nanozyme-based kit for cTnI detection in human serum
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Journal Article
A ultra-stable point of care nanozyme-based kit for cTnI detection in human serum
2025
Overview
Home discovery of myocardial infarction can significantly improve the rate of treatment. Cardiac troponin I (cTnI), as a biochemical marker that has been introduced into clinical diagnosis and treatment guidelines, can effectively predict the occurrence of myocardial infarction. We constructed highly stable nanozyme based on Fe 3 O 4 nanoparticles and prepared rapid detection reagents for myocardial infarction by modifying anti-cTnI antibodies. The results showed that the nanozyme with an average particle size of 200 nm had peroxidase activity and could effectively catalyze 3,3′, 5,5′-tetramethylbenzidine (TMB). With a sensitivity of up to 1.5 ng/mL, the kit showed superior performance than commercial colloidal gold assay kits, and could effectively detect cTnI in serum with an overall compliance rate of 92.1%. The study provides a new approach to home detection of heart attacks.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
