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Prevalence of Clinical Isolates of Cryptococcus gattii Serotype C among Patients with AIDS in Sub-Saharan Africa
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Prevalence of Clinical Isolates of Cryptococcus gattii Serotype C among Patients with AIDS in Sub-Saharan Africa
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Journal Article
Prevalence of Clinical Isolates of Cryptococcus gattii Serotype C among Patients with AIDS in Sub-Saharan Africa
2005
Overview
Cryptococcus gattii is a group of exogenous, neurotropic yeasts that possess the capsular serotype B or C. Isolates of serotype C are extremely rare and, until recently, were known to infect only immunocompetent individuals. We genotyped 176 isolates of Cryptococcus from patients in sub-Saharan Africa who had AIDS; 22 (13.7%) of 161 isolates from Botswana and 2 (13.3%) of 15 isolates from Malawi were C. gattii serotype C strains. All of these serotype C strains belong to the rare VGIV genotype, possess the MATα mating-type allele, and exhibit little genetic diversity
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
Acquired Immunodeficiency Syndrome - microbiology
/ AIDS
/ Alleles
/ Animals
/ Biological and medical sciences
/ Botswana
/ Cryptococcosis - microbiology
/ Cryptococcus - isolation & purification
/ DNA, Ribosomal Spacer - chemistry
/ DNA, Ribosomal Spacer - genetics
/ Fundamental and applied biological sciences. Psychology
/ Fungi
/ Humans
/ Malawi
/ Polymorphism, Restriction Fragment Length
