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Declining Incidence of Invasive Streptococcus pneumoniae Infections among Persons with AIDS in an Era of Highly Active Antiretroviral Therapy, 1995—2000
by
Hadler, James L.
, Harrison, Lee H.
, Khoshnood, Kaveh
, Schuchat, Anne
, Barrett, Nancy L.
, Gallagher, Kathleen M.
, Holford, Theodore R.
, Heffernan, Richard T.
, Reingold, Arthur L.
in
Acquired Immunodeficiency Syndrome - drug therapy
/ Adolescent
/ Adult
/ African Americans
/ AIDS
/ AIDS-Related Opportunistic Infections - epidemiology
/ AIDS-Related Opportunistic Infections - ethnology
/ Antiretroviral Therapy, Highly Active
/ Biological and medical sciences
/ Disease incidence rates
/ Disease risk
/ Epidemiology
/ European Continental Ancestry Group
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Highly active antiretroviral therapy
/ Hispanic Americans
/ HIV
/ HIV/AIDS
/ Human viral diseases
/ Humans
/ Incidence
/ Infections
/ Infectious diseases
/ Male
/ Medical sciences
/ Metropolitan areas
/ Microbiology
/ Middle Aged
/ Pneumococcal Infections - epidemiology
/ Pneumococcal Infections - ethnology
/ Preventive medicine
/ Retrospective Studies
/ Streptococcus pneumoniae
/ Surveillance
/ United States - epidemiology
/ Viral diseases
/ Viral diseases of the lymphoid tissue and the blood. Aids
2005
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Declining Incidence of Invasive Streptococcus pneumoniae Infections among Persons with AIDS in an Era of Highly Active Antiretroviral Therapy, 1995—2000
by
Hadler, James L.
, Harrison, Lee H.
, Khoshnood, Kaveh
, Schuchat, Anne
, Barrett, Nancy L.
, Gallagher, Kathleen M.
, Holford, Theodore R.
, Heffernan, Richard T.
, Reingold, Arthur L.
in
Acquired Immunodeficiency Syndrome - drug therapy
/ Adolescent
/ Adult
/ African Americans
/ AIDS
/ AIDS-Related Opportunistic Infections - epidemiology
/ AIDS-Related Opportunistic Infections - ethnology
/ Antiretroviral Therapy, Highly Active
/ Biological and medical sciences
/ Disease incidence rates
/ Disease risk
/ Epidemiology
/ European Continental Ancestry Group
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Highly active antiretroviral therapy
/ Hispanic Americans
/ HIV
/ HIV/AIDS
/ Human viral diseases
/ Humans
/ Incidence
/ Infections
/ Infectious diseases
/ Male
/ Medical sciences
/ Metropolitan areas
/ Microbiology
/ Middle Aged
/ Pneumococcal Infections - epidemiology
/ Pneumococcal Infections - ethnology
/ Preventive medicine
/ Retrospective Studies
/ Streptococcus pneumoniae
/ Surveillance
/ United States - epidemiology
/ Viral diseases
/ Viral diseases of the lymphoid tissue and the blood. Aids
2005
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Declining Incidence of Invasive Streptococcus pneumoniae Infections among Persons with AIDS in an Era of Highly Active Antiretroviral Therapy, 1995—2000
by
Hadler, James L.
, Harrison, Lee H.
, Khoshnood, Kaveh
, Schuchat, Anne
, Barrett, Nancy L.
, Gallagher, Kathleen M.
, Holford, Theodore R.
, Heffernan, Richard T.
, Reingold, Arthur L.
in
Acquired Immunodeficiency Syndrome - drug therapy
/ Adolescent
/ Adult
/ African Americans
/ AIDS
/ AIDS-Related Opportunistic Infections - epidemiology
/ AIDS-Related Opportunistic Infections - ethnology
/ Antiretroviral Therapy, Highly Active
/ Biological and medical sciences
/ Disease incidence rates
/ Disease risk
/ Epidemiology
/ European Continental Ancestry Group
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Highly active antiretroviral therapy
/ Hispanic Americans
/ HIV
/ HIV/AIDS
/ Human viral diseases
/ Humans
/ Incidence
/ Infections
/ Infectious diseases
/ Male
/ Medical sciences
/ Metropolitan areas
/ Microbiology
/ Middle Aged
/ Pneumococcal Infections - epidemiology
/ Pneumococcal Infections - ethnology
/ Preventive medicine
/ Retrospective Studies
/ Streptococcus pneumoniae
/ Surveillance
/ United States - epidemiology
/ Viral diseases
/ Viral diseases of the lymphoid tissue and the blood. Aids
2005
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Declining Incidence of Invasive Streptococcus pneumoniae Infections among Persons with AIDS in an Era of Highly Active Antiretroviral Therapy, 1995—2000
Journal Article
Declining Incidence of Invasive Streptococcus pneumoniae Infections among Persons with AIDS in an Era of Highly Active Antiretroviral Therapy, 1995—2000
2005
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Overview
Background. Our goal was to describe trends in invasive pneumococcal disease incidence among persons with acquired immunodeficiency syndrome (AIDS) since the introduction of highly active antiretroviral therapy (HAART). Methods. We used time-trend analysis of annual invasive pneumococcal disease incidence rates froma populationbased, active surveillance system. Annual incidence rates were calculated for 5 July–June periods by use of data from San Francisco county, the 6-county Baltimore metropolitan area, and Connecticut. The numerators were the numbers of invasive Streptococcus pneumoniae infections among persons 18–64 years of age with AIDS; the denominators were the numbers of persons living with AIDS, estimated on the basis of AIDS surveillance data. Results. The annual incidence of invasive pneumococcal disease declined from 1094 cases/100,000 persons with AIDS (July 1995–June 1996) to 467 cases/100,000 persons living with AIDS (July 1999–June 2000). The annual percentage changes in incidence were −34%, −29%, −8%, and −1%. Declines were similar by surveillance area, sex, and race/ethnicity. During the final year of the study, the invasive pneumococcal disease incidence in persons with AIDS was half that of the pre-HAART era but was still 35 times higher than that in similarly aged non—HIV-infected adults. Conclusions. In the United States, invasive pneumococcal disease incidence declined sharply across a range of subgroups living with AIDS during the period after widespread introduction of HAART. Despite these gains, persons with AIDS remain at high risk for invasive pneumococcal disease.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
Acquired Immunodeficiency Syndrome - drug therapy
/ Adult
/ AIDS
/ AIDS-Related Opportunistic Infections - epidemiology
/ AIDS-Related Opportunistic Infections - ethnology
/ Antiretroviral Therapy, Highly Active
/ Biological and medical sciences
/ European Continental Ancestry Group
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Highly active antiretroviral therapy
/ HIV
/ HIV/AIDS
/ Humans
/ Male
/ Pneumococcal Infections - epidemiology
/ Pneumococcal Infections - ethnology
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