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Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis

by Padula, Steven J , Marrakchi, Slaheddine , Thoma, Christian , Turki, Hamida , Burden, A. David , Shear, Michael , Baum, Patrick , Choon, Siew-Eng , Bachelez, Hervé , Morita, Akimichi , Hall, David B , Tsai, Tsen-Fang

in Administration, Intravenous / Antibodies, Monoclonal, Humanized - administration & dosage / Antibodies, Monoclonal, Humanized - immunology / Antibodies, Monoclonal, Humanized - therapeutic use / Cytokines / Drug dosages / Female / Humans / Interleukins - genetics / Interleukins - metabolism / Male / Monoclonal antibodies / Mutation / Psoriasis / Psoriasis - drug therapy / Receptors, Interleukin - antagonists & inhibitors / Severity of Illness Index / Skin diseases

2019

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Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis

2019

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Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis

2019

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Journal Article

Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis

Padula, Steven J,

Marrakchi, Slaheddine,

Thoma, Christian,

Turki, Hamida,

Burden, A. David,

Shear, Michael,

Baum, Patrick,

Choon, Siew-Eng,

Bachelez, Hervé,

Morita, Akimichi,

Hall, David B,

Tsai, Tsen-Fang

2019

Overview

Seven patients with pustular psoriasis, three with mutations in IL36RN , were treated with a monoclonal antibody against interleukin-36 receptor and had amelioration of their skin disease.

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Publisher

Massachusetts Medical Society

Subject

Administration, Intravenous

/ Antibodies, Monoclonal, Humanized - administration & dosage

/ Antibodies, Monoclonal, Humanized - immunology

/ Antibodies, Monoclonal, Humanized - therapeutic use

/ Cytokines

/ Drug dosages

/ Female