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Unravelling biology and shifting paradigms in cancer with single-cell sequencing
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Journal Article
Unravelling biology and shifting paradigms in cancer with single-cell sequencing
2017
Overview
In this Opinion article, Baslan and Hicks discuss how single-cell sequencing could be used to advance our understanding of tumour biology and genetics, in addition to translational applications in the clinic.
The fundamental operative unit of a cancer is the genetically and epigenetically innovative single cell. Whether proliferating or quiescent, in the primary tumour mass or disseminated elsewhere, single cells govern the parameters that dictate all facets of the biology of cancer. Thus, single-cell analyses provide the ultimate level of resolution in our quest for a fundamental understanding of this disease. Historically, this quest has been hampered by technological shortcomings. In this Opinion article, we argue that the rapidly evolving field of single-cell sequencing has unshackled the cancer research community of these shortcomings. From furthering an elemental understanding of intra-tumoural genetic heterogeneity and cancer genome evolution to illuminating the governing principles of disease relapse and metastasis, we posit that single-cell sequencing promises to unravel the biology of all facets of this disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group
