Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Exosome-Based Regimen Rescues Endometrial Fibrosis in Intrauterine Adhesions Via Targeting Clinical Fibrosis Biomarkers

by Zhang, Yanye , Wu, Yiqing , Zhao, Wei , Ye, Xiaohang , Jin, Jiani , Li, Xiaoqing , Liu, Juan , Zhang, Dan , Xue, Jinglei , Gao, Jianqing , Li, Jiaqun , Zhang, Runju , Lin, Yifeng , Chen, Panpan , Zheng, Junyan , Sun, Jiwei , Sun, Xiao , Li, Yaoshen , Chen, Chuan , Jiang, Xin-Chi

in Biomarkers / Collagen / Collagen (type I) / Enabling Technologies for Cell-Based Clinical Translation / Endometrium / Exosomes / Female / Fibrosis / Humans / Infertility / Mesenchymal stem cells / Patients / Recovery of function / Structure-function relationships / Tissue Adhesions - drug therapy / Tissue Adhesions - pathology / Uterine Diseases - pathology / Uterine Diseases - therapy / Uterus / Vimentin / Vimentin - therapeutic use

2023

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Exosome-Based Regimen Rescues Endometrial Fibrosis in Intrauterine Adhesions Via Targeting Clinical Fibrosis Biomarkers

2023

Confirm

Do you wish to request the book?

Exosome-Based Regimen Rescues Endometrial Fibrosis in Intrauterine Adhesions Via Targeting Clinical Fibrosis Biomarkers

2023

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Exosome-Based Regimen Rescues Endometrial Fibrosis in Intrauterine Adhesions Via Targeting Clinical Fibrosis Biomarkers

Zhang, Yanye,

Wu, Yiqing,

Zhao, Wei,

Ye, Xiaohang,

Jin, Jiani,

Li, Xiaoqing,

Liu, Juan,

Zhang, Dan,

Xue, Jinglei,

Gao, Jianqing,

Li, Jiaqun,

Zhang, Runju,

Lin, Yifeng,

Chen, Panpan,

Zheng, Junyan,

Sun, Jiwei,

Sun, Xiao,

Li, Yaoshen,

Chen, Chuan,

Jiang, Xin-Chi

2023

Overview

Abstract Intrauterine adhesions (IUA), which is characterized by endometrial fibrosis, continue to be the most common cause of uterine infertility globally. Our work revealed that 3 fibrotic progression markers (Vimentin, COL5A2, and COL1A1) were significantly increased in the endometrium of IUA patients. Mesenchymal stem cell–derived exosomes (EXOs) have been recently revealed as a cell-free therapy for fibrosis diseases. Nevertheless, the application of EXOs is restricted by the short residency duration in the target tissue. To overcome this limitation, herein, we reported an exosome–based regimen (EXOs-HP) that thermosensitive poloxamer hydrogel possessed the ability to efficiently promote the residency duration of EXOs in the uterine cavity. By downregulating fibrotic progression markers (Vimentin, COL5A2, and COL1A1), EXOs-HP could significantly restore the function and structure of the injured endometrium in the IUA model. Our work provides the theoretical and experimental foundation of EXOs-HP in treating IUA, highlighting the clinical potential of topical EXOs-HP delivery system in IUA patients. Graphical Abstract In this study, we identified 3 upregulated fibrotic progression markers (Vimentin, COL5A2, and COL1A1) in the endometrium of IUA patients and highlighted the efficacious therapy of EXOs–HP via inhibiting the fibrosis process.

Share this book

Add to My Shelf

Publisher

Oxford University Press

Subject

Biomarkers

/ Collagen

/ Collagen (type I)

/ Enabling Technologies for Cell-Based Clinical Translation

/ Endometrium

/ Exosomes

/ Female