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Progressive Infection in a Subset of HIV-1—Positive Chimpanzees
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Progressive Infection in a Subset of HIV-1—Positive Chimpanzees
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Journal Article
Progressive Infection in a Subset of HIV-1—Positive Chimpanzees
2000
Overview
Chimpanzees are susceptible to infection with human immunodeficiency virus (HIV)—1; however, infected animals usually maintain normal numbers of CD4+ T lymphocytes and do not develop immunodeficiency. We have examined 10 chronically infected HIV-1—positive chimpanzees for evidence of progressive infection. In addition to 1 animal that developed AIDS, 3 chimpanzees exhibit evidence of progressive HIV infection. All progressors have low CD4+ T cell counts (<200 cells/µL), severe CD4:CD8 inversion, and marked reduction in interleukin-2 receptor expression by CD4+ T cells. In comparison with HIV-positive nonprogressor chimpanzees, progressors have higher plasma and lymphoid virus loads, greater CD38 expression in CD8+/HLA-DR+ T cells, and greater serum concentrations of soluble tumor necrosis factor type II receptors and β2-microglobulin, all markers of HIV progression in humans. These observations show that progressive HIV-1 infection can occur in chimpanzees and suggest that the pathogenesis of progressive infection in this species resembles that in humans.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
Acquired Immunodeficiency Syndrome - immunology
/ Acquired Immunodeficiency Syndrome - physiopathology
/ AIDS
/ Animals
/ Antigens, Differentiation - blood
/ Biological and medical sciences
/ Experimental viral diseases and models
/ Female
/ HIV
/ HIV 1
/ HIV Infections - physiopathology
/ HIV Seropositivity - immunology
/ HIV Seropositivity - pathology
/ HIV Seropositivity - physiopathology
/ Human immunodeficiency virus 1
/ Humans
/ Lymphocyte Subsets - immunology
/ Male
/ Receptors, Interleukin-2 - blood
/ RNA
/ Viruses
