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Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967

by Chen, Jih-Jung , Kuo, Yueh-Hsiung , Lee, Tzong-Huei , Wang, Shih-Wei , Chiang, Yin-Ru , Shih, Tsai-Yen , Pang, Ka-Lai

in Acetates / Acetic acid / Algae / Angiogenesis / Animals / Antiangiogenics / Anticancer properties / Antiinfectives and antibacterials / Antimicrobial activity / antimicrobial properties / Antineoplastic Agents - pharmacology / Aspergillus / Aspergillus - chemistry / Aspergillus giganteus / aspergilsmin / bioactive natural products / Biocompatibility / Cancer / Carbon / cell growth / Cell Line, Tumor - drug effects / Cell Proliferation - drug effects / Cells (biology) / chromatography / Column chromatography / Cytotoxicity / Disease resistance / Ethyl acetate / Fermentation / Fermented fish paste / Fermented food / Fungi / Hepatocellular carcinoma / hepatoma / Humans / Inhibitory Concentration 50 / Liver cancer / Metabolites / Neoplasms / Oceans and Seas / Oxygenation / Patulin / PC-3 Cells - drug effects / Polyketides / Polyketides - pharmacology / Progenitor cells / Prostate cancer / prostatic neoplasms / solid state fermentation / Spectral analysis / Spectrum analysis / Stem cells / Toxicity / Trichocomaceae / Ulva lactuca

2020

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Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967

by Chen, Jih-Jung , Kuo, Yueh-Hsiung , Lee, Tzong-Huei , Wang, Shih-Wei , Chiang, Yin-Ru , Shih, Tsai-Yen , Pang, Ka-Lai

2020

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Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967

by Chen, Jih-Jung , Kuo, Yueh-Hsiung , Lee, Tzong-Huei , Wang, Shih-Wei , Chiang, Yin-Ru , Shih, Tsai-Yen , Pang, Ka-Lai

2020

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Journal Article

Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967

Chen, Jih-Jung,

Kuo, Yueh-Hsiung,

Lee, Tzong-Huei,

Wang, Shih-Wei,

Chiang, Yin-Ru,

Shih, Tsai-Yen,

Pang, Ka-Lai

2020

Overview

Agar-based disc diffusion antimicrobial assay has shown that the ethyl acetate extract of the fermented broth of Aspergillus giganteus NTU967 isolated from Ulva lactuca exhibited significant antimicrobial activity in our preliminary screening of bioactive fungal strains. Therefore, column chromatography of the active principles from liquid- and solid–state fermented products of the fungal strain was carried out, and which had led to isolation of eleven compounds. Their structures were determined by spectral analysis to be seven new highly oxygenated polyketides, namely aspergilsmins A–G (1–7), along with previously reported patulin, deoxytryptoquivaline, tryptoquivaline and quinadoline B. Among these, aspergilsmin C (3) and patulin displayed promising anticancer activities against human hepatocellular carcinoma SK-Hep-1 cells and prostate cancer PC-3 cells with IC50 values between 2.7–7.3 μM. Furthermore, aspergilsmin C (3) and patulin exhibited significant anti-angiogenic functions by impeding cell growth and tube formation of human endothelial progenitor cells without any cytotoxicity.

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Publisher

MDPI AG,MDPI

Subject

/ Algae

/ Animals

/ Anticancer properties