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Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients

by Makkar, Raj R , Fearon, William F , Zajarias, Alan , Brown, David L , Hahn, Rebecca T , Pichard, Augusto D , Dewey, Todd , Mack, Michael J , Smith, Craig R , Babaliaros, Vasilis , Webb, John G , Kodali, Susheel K , Moses, Jeffrey W , Greason, Kevin L , Jaber, Wael A , Kereiakes, Dean , Thourani, Vinod H , Doshi, Darshan , Szeto, Wilson Y , Pibarot, Philippe , Svensson, Lars G , Kapadia, Samir , Williams, Mathew R , Cohen, David J , Tuzcu, E. Murat , Hodson, Robert W , Alu, Maria C , Miller, D. Craig , Leon, Martin B , Herrmann, Howard C , Trento, Alfredo , Whisenant, Brian K , Anderson, William N

in Aged / Aged, 80 and over / Aortic stenosis / Aortic Valve Stenosis - diagnostic imaging / Aortic Valve Stenosis - mortality / Aortic Valve Stenosis - surgery / Cardiovascular disease / Clinical trials / Coronary vessels / Death / Female / Fibrillation / Heart surgery / Heart Valve Prosthesis / Heart Valve Prosthesis Implantation - methods / Heart Valve Prosthesis Implantation - mortality / Humans / Kaplan-Meier Estimate / Male / Multivariate Analysis / Postoperative Complications - mortality / Regurgitation / Risk Factors / Risk groups / Stenosis / Stroke - etiology / Stroke - mortality / Surgery / Surgical techniques / Transcatheter Aortic Valve Replacement / Ultrasonography

2016

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2016

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2016

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Journal Article

Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients

Makkar, Raj R,

Fearon, William F,

Zajarias, Alan,

Brown, David L,

Hahn, Rebecca T,

Pichard, Augusto D,

Dewey, Todd,

Mack, Michael J,

Smith, Craig R,

Babaliaros, Vasilis,

Webb, John G,

Kodali, Susheel K,

Moses, Jeffrey W,

Greason, Kevin L,

Jaber, Wael A,

Kereiakes, Dean,

Thourani, Vinod H,

Doshi, Darshan,

Szeto, Wilson Y,

Pibarot, Philippe,

Svensson, Lars G,

Kapadia, Samir,

Williams, Mathew R,

Cohen, David J,

Tuzcu, E. Murat,

Hodson, Robert W,

Alu, Maria C,

Miller, D. Craig,

Leon, Martin B,

Herrmann, Howard C,

Trento, Alfredo,

Whisenant, Brian K,

Anderson, William N

2016

Overview

In a randomized trial involving more than 2000 patients, transcatheter aortic-valve replacement was noninferior to surgical replacement in the primary end point of death from any cause or disabling stroke at 2 years. Transcatheter aortic-valve replacement (TAVR) is a new therapy for patients with severe aortic stenosis who are not candidates for surgery 1 , 2 or who are at high risk for complications due to surgery. 3 , 4 The acceptance of the use of TAVR in high-risk patients was based on evidence from clinical trials 5 , 6 that used early-generation TAVR devices; these procedures were associated with considerable procedure-related complications. 7 – 9 Recently, increased operator experience and enhanced transcatheter valve systems have led to a worldwide trend to use TAVR in patients who are at low or intermediate risk. 10 – 12 This trend has been evaluated in small . . .

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Aged, 80 and over

/ Aortic stenosis

/ Aortic Valve Stenosis - diagnostic imaging

/ Aortic Valve Stenosis - mortality

/ Aortic Valve Stenosis - surgery

/ Cardiovascular disease