Journal Article

Features of Distribution of the Allelic Variant of the OAS1 Gene Associated with Severe Form of the Coronavirus Infection in the Russian and Global Populations

Alimov, A. A., Petrushenko, V. S., Olkova, M. V., Koshel, S. M.

2023

Overview

The study of the geographic distribution of the allelic variant of the OAS1 gene associated with severe form of the infections caused by RNA viruses was carried out using the rs10774671 polymorphic locus. The mutant allele encoding the p42 protein isoform was most prevalent in the Russian populations. A comparative analysis of the prevalence of the mutant allele in world populations showed that its frequency is 0.9 among the inhabitants of Northern Eurasia, while the allele encoding the p46 protein isoform is widespread among the population of West Central Africa. A cartographic analysis of the relationship between the population—frequency characteristics of the marker alleles and the geographical remoteness of the populations showed that the mutant allele is most often observed in the indigenous populations of the Far East, which suggests its East Asian origin.

• Publisher: Springer US,Springer,Springer Nature B.V
• Subject: 2',5'-Oligoadenylate Synthetase - genetics / Alleles / Analysis / Biomedical and Life Sciences / Biomedicine / Cell Biology / Comparative analysis / Coronavirus Infections - genetics / Coronaviruses / COVID-19 / Dengue fever / Gene Frequency / Gene mutations / Genes / Genetic aspects / Genetics / Genomes / Genotype & phenotype / Geographical distribution / Geography / Health aspects / Humans / Infection / Infections / Internal Medicine / Laboratory Medicine / Mutants / p42 Protein / p46 Protein / Pathology / Population genetics / Population studies / Protein Isoforms - genetics / Proteins / RNA / RNA viruses / Russia - epidemiology / Severe acute respiratory syndrome coronavirus 2 / Viral infections / Viruses / West Nile virus