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Strontium ranelate does not stimulate bone formation in ovariectomized rats
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Strontium ranelate does not stimulate bone formation in ovariectomized rats
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Journal Article
Strontium ranelate does not stimulate bone formation in ovariectomized rats
2008
Overview
Introduction
Strontium ranelate (SrR) is suggested to function as a dual-acting agent in the treatment of postmenopausal osteoporosis with anti-resorptive and anabolic skeletal benefits. We evaluated the effects of SrR on the skeleton in ovariectomized (OVX) rats and evaluated the influence of dietary calcium.
Methods
Three-month old virgin female rats underwent ovariectomy (OVX, n = 50) or SHAM surgery (SHAM, n = 10). Four weeks post-surgery, rats were treated daily by oral gavage with distilled water (10 ml/kg/day) or SrR (25 or 150 mg/kg/day) for 90 days. Separate groups of animals for each dose of SrR were fed a low (0.1%) or normal (1.19%) calcium (Ca) diet. Static and dynamic histomorphometry, DXA, μ-CT, mechanical testing, and serum and skeletal concentrations of strontium were assessed.
Results
SrR at doses of 25 and 150 mg/kg/day did not increase bone formation on trabecular or periosteal bone surfaces, and failed to inhibit bone resorption of trabecular bone regardless of Ca intake. There were no improvements in bone mass, volume or strength with either dose of SrR given normal Ca.
Conclusion
These findings demonstrate that SrR at dosages of 25 and 150 mg/kg/day did not stimulate an anabolic bone response, and failed to improve the bone biomechanical properties of OVX rats.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Animals
/ Biological and medical sciences
/ Bone Density Conservation Agents - pharmacology
/ Bone Resorption - physiopathology
/ Bone Resorption - prevention & control
/ Calcium
/ Calcium, Dietary - pharmacology
/ Diseases of the osteoarticular system
/ Dose-Response Relationship, Drug
/ Drug Evaluation, Preclinical - methods
/ Dual energy X-ray absorptiometry
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Lumbar Vertebrae - drug effects
/ Lumbar Vertebrae - physiopathology
/ Medicine
/ Mineralization, calcification
/ Molecular and cellular biology
/ Organometallic Compounds - pharmacokinetics
/ Organometallic Compounds - pharmacology
/ Osteoporosis. Osteomalacia. Paget disease
/ Rats
/ Rodents
/ Skeleton
/ Surgery
