Asset Details
Do you wish to reserve the book?
P-glycoprotein inhibition increases the transport of dauricine across the blood-brain barrier
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
P-glycoprotein inhibition increases the transport of dauricine across the blood-brain barrier
Do you wish to request the book?
P-glycoprotein inhibition increases the transport of dauricine across the blood-brain barrier
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
P-glycoprotein inhibition increases the transport of dauricine across the blood-brain barrier
2014
Overview
Dauricine is the major bioactive component isolated from the roots of Menispermum dauricum D.C. The aim of the present study was to investigate the role of P-glycoprotein in the transport of dauricine across the blood-brain barrier by pre-treatment with the P-glycoprotein inhibitor verapamil. Sprague Dawley rats were divided into a verapamil group (pretreated with verapamil at a dose of 20 mg/kg) and a control group (pretreated with the same volume of normal saline). After 90 min, the animals were injected intravenously with dauricine (10 mg/kg). At 15, 30 and 60 min after dauricine administration, the levels of dauricine in the blood and brain were detected by high-performance liquid chromatography. Compared with the control group, the dauricine concentration in the brains of the rats in the verapamil group was significantly increased. Furthermore, the brain-plasma ratio of dauricine in the rats pretreated with verapamil was significantly higher than that of the animals in the control group. However, there was no difference identified between dauricine levels in the plasma of the verapamil and the control groups. The results indicated that dauricine is able to pass the blood-brain barrier, and that P-glycoprotein has an important role in the transportation of dauricine across the blood-brain barrier.
Publisher
D.A. Spandidos,Spandidos Publications,Spandidos Publications UK Ltd
Subject
/ Animals
/ ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors
/ ATP Binding Cassette Transporter, Sub-Family B - metabolism
/ Benzylisoquinolines - analysis
/ Benzylisoquinolines - pharmacology
/ Biological Transport - drug effects
/ Blood-Brain Barrier - drug effects
/ Blood-Brain Barrier - metabolism
/ Chromatography, High Pressure Liquid
/ Drugs
/ High-performance liquid chromatography
/ Ischemia
/ Male
/ Plasma
/ Rats
/ Tetrahydroisoquinolines - analysis
/ Tetrahydroisoquinolines - pharmacology
/ Traditional Chinese medicine
