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Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

by Maxime, Virginie , Baudin, François , Quenot, Jean-Pierre , Forceville, Xavier , Martin, Claude , Slama, Michel , Petitpas, Franck , Bohé, Julien , Cook, Fabrice , Ali Benali, Mohamed , Combes, Alain , Dargent, Auguste , Annane, Djillali , Timsit, Jean-François , Schwebel, Carole , Loriferne, Jean-François , Hissem, Tarik , Siami, Shidasp , Chimot, Loïc , Boulain, Thierry , Constantin, Jean-Michel , Amathieu, Roland , Asehnoune, Karim , Capellier, Gilles , Bellissant, Eric , Dhonneur, Gilles , Colin, Gwenhael , Megarbane, Bruno , Souweine, Bertrand , Brun-Buisson, Christian , Leroy, Olivier , Renault, Alain , Cariou, Alain , Mercier, Emmanuelle , François, Bruno , Charpentier, Claire , Misset, Benoît

in Aged / Anesthesia & intensive care / Anesthésie & soins intensifs / Anti-Inflammatory Agents - adverse effects / Anti-Inflammatory Agents - therapeutic use / Anti-Inflammatory Agents/adverse effects/therapeutic use / Blood pressure / Cause of Death / Clinical outcomes / Clinical trials / Combined Modality Therapy / Cortisone / Double-Blind Method / Drug administration / Drug Therapy, Combination / Female / Fludrocortisone - adverse effects / Fludrocortisone - therapeutic use / Fludrocortisone/adverse effects/therapeutic use / Hormones / Human health sciences / Humans / Hydrocortisone / Hydrocortisone - adverse effects / Hydrocortisone - therapeutic use / Hydrocortisone/adverse effects/therapeutic use / Hyperglycemia / Infections / Investigations / Life Sciences / Male / Mechanical ventilation / Middle Aged / Mortality / Organ Dysfunction Scores / Recurrence / Renal Replacement Therapy / Respiration, Artificial / Sciences de la santé humaine / Sepsis / Septic shock / Shock, Septic - complications / Shock, Septic - drug therapy / Shock, Septic - mortality / Shock, Septic - therapy / Shock, Septic/complications/drug therapy/mortality/therapy / Simplified Acute Physiology Score / Steroids / Survival Analysis / Treatment Outcome

2018

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Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

2018

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2018

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Journal Article

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

Maxime, Virginie,

Baudin, François,

Quenot, Jean-Pierre,

Forceville, Xavier,

Martin, Claude,

Slama, Michel,

Petitpas, Franck,

Bohé, Julien,

Cook, Fabrice,

Ali Benali, Mohamed,

Combes, Alain,

Dargent, Auguste,

Annane, Djillali,

Timsit, Jean-François,

Schwebel, Carole,

Loriferne, Jean-François,

Hissem, Tarik,

Siami, Shidasp,

Chimot, Loïc,

Boulain, Thierry,

Constantin, Jean-Michel,

Amathieu, Roland,

Asehnoune, Karim,

Capellier, Gilles,

Bellissant, Eric,

Dhonneur, Gilles,

Colin, Gwenhael,

Megarbane, Bruno,

Souweine, Bertrand,

Brun-Buisson, Christian,

Leroy, Olivier,

Renault, Alain,

Cariou, Alain,

Mercier, Emmanuelle,

François, Bruno,

Charpentier, Claire,

Misset, Benoît

2018

Overview

Septic shock is characterized by a dysregulated host response to infection and is associated with a mortality of 45 to 50%. In this multicenter, randomized, double-blind, placebo-controlled trial in 1241 patients, hydrocortisone plus fludrocortisone reduced 90-day mortality.

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Anesthesia & intensive care

/ Anesthésie & soins intensifs

/ Anti-Inflammatory Agents - adverse effects

/ Anti-Inflammatory Agents - therapeutic use

/ Anti-Inflammatory Agents/adverse effects/therapeutic use

/ Blood pressure