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The bcl-2 gene encodes a novel G protein
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Journal Article
The bcl-2 gene encodes a novel G protein
1989
Overview
LITTLE is known about the biochemical or functional nature of the proteins encoded by the bcl-2 gene, which undergoes chromosomal translocation in approximately 85% of follicular lymphoma, 20% of diffuse large cell lymphoma and 10% of chronic lymphocytic leukaemia of B cells
1–5
. Translocation of bcl-2 sequences
5
from chromosome 18 to the
J
H
segment of the immunoglobulin gene at chromosome band 14q32 in B cells results in deregulated expression of this gene, causing high steady state levels of
bcl-2
messenger RNA
2
. DNA sequence data indicate that
bcl-2
encodes two proteins by virtue of alternative splicing, designated as Bcl-2α and Bcl-2β, with relative molecular masses of 26,000 and 22,000 respectively
1
. Cell fractionation experiments indicate that the
bcl-2
α gene product is located at the inner surface of the cell membrane, suggesting a possible role in mitogenic signal transduction
6
. We report here that Bcl-2α has GTP-binding activity and a protein sequence that suggests it belongs to the small molecular weight GTP-binding protein (G protein) family
7–16
.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Animals
/ Biological and medical sciences
/ Epitopes
/ Fundamental and applied biological sciences. Psychology
/ Genetics
/ GTP-Binding Proteins - genetics
/ GTP-Binding Proteins - immunology
/ GTP-Binding Proteins - metabolism
/ guanine nucleotide-binding protein
/ Guanosine Triphosphate - metabolism
/ Humanities and Social Sciences
/ Humans
/ letter
/ Leukemia
/ Lymphoma
/ Mice
/ Molecular and cellular biology
/ Proto-Oncogene Proteins - genetics
/ Proto-Oncogene Proteins - immunology
/ Proto-Oncogene Proteins - metabolism
/ Proto-Oncogene Proteins c-bcl-2
/ Science
