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miR-361-5p contributes to the pathogenesis of Alzheimer’s disease
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miR-361-5p contributes to the pathogenesis of Alzheimer’s disease
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miR-361-5p contributes to the pathogenesis of Alzheimer’s disease
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Journal Article
miR-361-5p contributes to the pathogenesis of Alzheimer’s disease
2025
Overview
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. This study investigated the roles of HOMER1, ATAD1, and miR-361 in AD pathogenesis using microarray (GSE106241, GSE157239; n = 60) and RT-PCR (n = 100; 50 AD patients, 50 controls from Northwest Iran) analyses. Decreased expression of HOMER1 and ATAD1, key regulators of glutamatergic synapses, and miR-361, a potential regulator of both, was observed in AD brain tissue (GSE106241, categorized into seven Braak stages), suggesting a link between their dysregulation, impaired synaptic function, and increased neuroinflammation. However, blood-based RT-PCR showed no significant difference in HOMER1 or ATAD1. miR-361 was significantly lower in AD patients (adjusted p < 0.043). These findings, limited by sample size and lacking a formal power analysis, require further investigation to validate their potential as peripheral biomarkers for AD. Future studies with larger sample sizes are warranted.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Aged
/ Alzheimer Disease - genetics
/ Alzheimer Disease - metabolism
/ Alzheimer Disease - pathology
/ ATAD1
/ Disease
/ DNA-Binding Proteins - genetics
/ DNA-Binding Proteins - metabolism
/ Female
/ Homer Scaffolding Proteins - genetics
/ Homer Scaffolding Proteins - metabolism
/ HOMER1
/ Humanities and Social Sciences
/ Humans
/ Male
/ Membrane Proteins - genetics
/ Membrane Proteins - metabolism
/ MIR-361
/ Proteins
/ Science
