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In Vitro and In Vivo Effects of Deoxyribonucleic Acid-Based Coatings Funtionalized with Vascular Endothelial Growth Factor
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In Vitro and In Vivo Effects of Deoxyribonucleic Acid-Based Coatings Funtionalized with Vascular Endothelial Growth Factor
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Journal Article
In Vitro and In Vivo Effects of Deoxyribonucleic Acid-Based Coatings Funtionalized with Vascular Endothelial Growth Factor
2007
Overview
Vascularization is important in wound healing and essential for tissue ingrowth into porous tissue-engineering matrices. Furthermore, peri-implant tissue vascularization is known to be important for the functionality of subcutaneously implanted biosensors (e.g., glucose sensors). As a first exploration of the use of deoxyribonucleic acid (DNA)-based coatings for the optimization of biosensor functionality, this study focused on the effect of DNA-based coatings functionalized with vascular endothelial growth factor (VEGF) on
in vitro
endothelial cell behavior and vascularization of the peri-implant tissue
in vivo
. To that end, DNA-based coatings consisting of poly-D-lysine and DNA were functionalized with different amounts of VEGF (25 and 250 ng) and compared to non-coated controls and non-functionalized DNA-based coatings. The results demonstrated the superiority of VEGF-functionalized DNA-based coatings in increasing endothelial cell proliferation and migration
in vitro
over non-coated controls and non-functionalized DNA-based coatings.
In vivo
, a significant increase in vascularization of the peri-implant area was observed for VEGF-functionalized DNA-based coatings. Because no dosage-dependent effects were observed, future experiments should focus on optimizing VEGF concentration for this purpose. Additionally, the administration of VEGF in combination with other (pro-angiogenic) factors should be considered.
Publisher
Mary Ann Liebert, Inc,SAGE Publications
Subject
/ Cell Movement - drug effects
/ Cell Proliferation - drug effects
/ Cell Survival - drug effects
/ Coated Materials, Biocompatible - administration & dosage
/ Coated Materials, Biocompatible - chemistry
/ DNA
/ Dose-Response Relationship, Drug
/ Endothelial Cells - cytology
/ Endothelial Cells - drug effects
/ Endothelial Cells - physiology
/ Humans
/ Male
/ Rats
/ Vascular Endothelial Growth Factor A - administration & dosage
