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Sonodynamically-induced Anticancer Effects of Polyethylene Glycol-Modified Carbon Nano Tubes
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Sonodynamically-induced Anticancer Effects of Polyethylene Glycol-Modified Carbon Nano Tubes
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Journal Article
Sonodynamically-induced Anticancer Effects of Polyethylene Glycol-Modified Carbon Nano Tubes
2020
Overview
Sonodynamic cancer therapy is based on the preferential uptake and/or retention of a sonosensitizing drug (sonosensitizer) in tumor tissues and the subsequent activation of the drug by ultrasound irradiation. In the present study, we investigated the sonodynamically-induced antitumoral effect with functionalized carbon nanotubes, such as poly-ethylene glycol-modified carbon nanotubes (PEG-modified CNTs).
Antitumor effects were evaluated using histological observation and assessing tumor growth following sonodynamic exposure to PEG-modified CNTs.
The combined treatment of 100 μM PEG-modified CNT and ultrasound induced a 2-fold cytotoxicity. Sodium azide, which quenches singlet oxygen, significantly inhibited ultrasonication induced cell damage in the presence of PEG-modified CNTs. This suggests that singlet oxygen produced by the combined use of PEG-modified CNTs and ultrasound is involved in the induction of antitumoral effects. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with PEG-modified CNTs, while neither the treatment with PEG-modified CNTs alone nor ultrasound alone caused any necrosis.
These results indicate that PEG-modified CNT functions as a sonosensitizer and is effective for sonochemical treatment of solid tumors.
Publisher
Anticancer Research USA Inc,International Institute of Anticancer Research
Subject
/ Animals
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - isolation & purification
/ Antineoplastic Agents - pharmacology
/ Ascites
/ Cancer
/ Carbon
/ Humans
/ Male
/ Mice
/ Nanotubes, Carbon - chemistry
/ Necrosis
/ Polyethylene Glycols - chemistry
/ Reactive Oxygen Species - metabolism
/ Sarcoma
/ Tubes
/ Tumors
