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T1R2/T1R3 polymorphism affects sweet and fat perception: Correlation between SNP and BMI in the context of obesity development
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T1R2/T1R3 polymorphism affects sweet and fat perception: Correlation between SNP and BMI in the context of obesity development
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Journal Article
T1R2/T1R3 polymorphism affects sweet and fat perception: Correlation between SNP and BMI in the context of obesity development
2025
Overview
Genetic variations in taste receptors are associated with gustatory perception and obesity, which in turn affects dietary preferences. Given the increasing tendency of people with obesity choosing sweet, high-fat meals, the current study assessed the cross-regulation of two polymorphisms of the sweet taste receptor (
T1R2/T1R3
), rs35874116 and rs307355, on fat sensitivity in Indian adults. We investigated the association between taste sensitivity and BMI in the
T1R2, T1R3
, and
CD36
polymorphic and non-polymorphic groups. The general labelled magnitude scale (gLMS) was used to assess the taste sensitivity of 249 participants in addition to anthropometric data. TaqMan Probe-based RT-PCR was employed to determine the polymorphisms. Additionally, the colorimetric method utilizing 3, 5-dinitro salicylic acid was used to evaluate the participants' salivary amylase activity. The mean detection thresholds for linoleic acid (LA) and sucrose were greater in individuals with obesity (i.e., 0.97 ± 0.08 mM and 0.22 ± 0.02 M, respectively) than in healthy adults (
p
< 0.0001), indicating lower sensitivity. Moreover, it was found that a greater proportion of persons with obesity fall into the polymorphic groups (i.e., 52% with genotype
CD36
AA, 44% with genotype
T1R2
CC, and 40% with genotype
T1R3
TT). All three single nucleotide polymorphisms support the Hardy–Weinberg equilibrium (
p
= 0.78). The Pearson correlation analysis between LA and the sucrose detection threshold revealed a significant (
p
< 0.0001) positive relationship with an
r
value of 0.5299. Moreover, salivary amylase activity was significantly (
p
< 0.05) higher in the polymorphic sub-groups. The results of our study imply that genetic variations in T1R2/T1R3 receptors affect perception of both sweetness and fat, which may have an effect on obesity.
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V
Subject
/ Amylases
/ Analysis
/ Biomedical and Life Sciences
/ Ethylenediaminetetraacetic acid
/ Female
/ genotype
/ Humans
/ India
/ Male
/ Obesity
/ people
/ Polymorphism, Single Nucleotide
/ Receptors, G-Protein-Coupled - genetics
/ Single nucleotide polymorphisms
/ Single-nucleotide polymorphism
/ Sucrose
/ Taste
