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Double-stranded DNA in exosomes： a novel biomarker in cancer detection
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Double-stranded DNA in exosomes： a novel biomarker in cancer detection
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Journal Article
Double-stranded DNA in exosomes： a novel biomarker in cancer detection
2014
Overview
Exosomes, small membrane vesicles （30-100 nm） of endocytic origin secreted by most cell types, contain functional biomolecules, which can be horizontally transferred to recipient cells [1]. Exosomes bear a specific protein and lipid composition, and carry a select set of functional mRNAs and microRNAs [2]. Recently, our group has shown that c-Met shed in exosomes can promote a proangiogenic and prometastatic phenotype in bone marrow-derived progenitor cells during melanoma progression [3]. In previous research, retrotransposon RNA transcripts, single-stranded DNA （ssDNA）,
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Biomedical and Life Sciences
/ Humans
/ Mice
/ microRNA
/ ssDNA
/ 单链DNA
/ 双链DNA
/ 生物分子
/ 生物标记物
/ 癌症检测
/ 细胞类型
