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Repolarizing macrophages improves breast cancer therapy
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Journal Article
Repolarizing macrophages improves breast cancer therapy
2017
Overview
Tumor-associated macrophages （TAMs） contribute to breast cancer progression and dissemination; TAM-targeting strategies aimed at their reprogramming show promising preelinical results. In a new report Guerriero and colleagues demonstrate that a novel HDAC Class IIa inhibitor, TMP195, can reprogram monocytes and macrophages in the tumor into cells able to sustain a robust CD8 T cell-mediated anti-tumoral immune response.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Benzamides - therapeutic use
/ Biomedical and Life Sciences
/ Breast Neoplasms - drug therapy
/ Breast Neoplasms - immunology
/ Cancer
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - pathology
/ Cellular Reprogramming - drug effects
/ Cellular Reprogramming - immunology
/ Female
/ Histone Deacetylase Inhibitors - therapeutic use
/ Humans
/ Immune response (cell-mediated)
