Journal Article

Dimensional representations of DSM-IV cluster B personality disorders in a population-based sample of Norwegian twins: a multivariate study

Reichborn-Kjennerud, T., Neale, M. C., Kendler, K. S., Torgersen, S., Czajkowski, N., Jacobson, K., Røysamb, E.

2008

Overview

The personality disorders (PDs) in the 'dramatic' cluster B [antisocial (ASPD), histrionic (HPD), narcissistic (NPD) and borderline (BPD)] demonstrate co-morbidity. However, the degree to which genetic and/or environmental factors influence their co-occurrence is not known and, with the exception of ASPD, the relative impact of genetic and environmental risk factors on liability to the cluster B PDs has not been conclusively established. PD traits were assessed in 1386 Norwegian twin pairs between the age of 19 and 35 years using the Structured Interview for DSM-IV Personality Disorders (SIDP-IV). Using the statistical package Mx, multivariate twin models were fitted to dimensional representations of the PDs. The best-fitting model, which did not include sex or shared family environment effects, included common genetic and environmental factors influencing all four dramatic PD traits, and factors influencing only ASPD and BPD. Heritability was estimated at 38% for ASPD traits, 31% for HPD traits, 24% for NPD traits and 35% for BPD traits. BPD traits had the lowest and ASPD traits the highest disorder-specific genetic variance. The frequently observed co-morbidity between cluster B PDs results from both common genetic and environmental influences. Etiologically, cluster B has a 'substructure' in which ASPD and BPD are more closely related to each other than to the other cluster B disorders.

• Publisher: Cambridge University Press
• Subject: Adult / Adult and adolescent clinical studies / Antisocial / Antisocial personality disorder / Antisocial Personality Disorder - diagnosis / Antisocial Personality Disorder - genetics / Antisocial Personality Disorder - psychology / Biological and medical sciences / borderline / Borderline Personality Disorder - diagnosis / Borderline Personality Disorder - genetics / Borderline Personality Disorder - psychology / Cohort Studies / Comorbidity / Diagnostic and Statistical Manual of Mental Disorders / Diseases in Twins - diagnosis / Diseases in Twins - genetics / Diseases in Twins - psychology / Disorders / Environmental aspects / Female / genetic / Genetics / Heritability / histrionic / Histrionic Personality Disorder - diagnosis / Histrionic Personality Disorder - genetics / Histrionic Personality Disorder - psychology / Home environment / Humans / Interviews / Liability / Male / Medical sciences / Mental disorders / Morbidity / Multivariate Analysis / Narcissism / narcissistic / Norway / Personality / Personality disorders / Personality Disorders - diagnosis / Personality Disorders - genetics / Personality Disorders - psychology / Personality traits / Psychology. Psychoanalysis. Psychiatry / Psychopathology. Psychiatry / Questionnaires / Risk Factors / Social Environment / Twins / Twins, Dizygotic - genetics / Twins, Dizygotic - psychology / Twins, Monozygotic - genetics / Twins, Monozygotic - psychology / Young Adult