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Serum metabolomics profiles in response to n-3 fatty acids in Chinese patients with type 2 diabetes: a double-blind randomised controlled trial
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Serum metabolomics profiles in response to n-3 fatty acids in Chinese patients with type 2 diabetes: a double-blind randomised controlled trial
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Journal Article
Serum metabolomics profiles in response to n-3 fatty acids in Chinese patients with type 2 diabetes: a double-blind randomised controlled trial
2016
Overview
We aimed to investigate the change of serum metabolomics in response to n-3 fatty acid supplements in Chinese patients with type 2 diabetes (T2D). In a double-blind parallel randomised controlled trial, 59 Chinese T2D patients were randomised to receive either fish oil (FO), flaxseed oil (FSO) or corn oil capsules (CO, served as a control group) and followed up for 180 days. An additional 17 healthy non-T2D participants were recruited at baseline for cross-sectional comparison between cases and non-cases. A total of 296 serum metabolites were measured among healthy controls and T2D patients before and after the intervention. Serum 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (CMPF) (
P
-interaction = 1.8 × 10
−7
) was the most significant metabolite identified by repeated-measures ANOVA, followed by eicosapentaenoate (
P
-interaction = 4.6 × 10
−6
), 1-eicosapentaenoylglycerophosphocholine (
P
-interaction = 3.4 × 10
−4
), docosahexaenoate (
P
-interaction = 0.001), linolenate (n-3 or n-6,
P
-interaction = 0.005) and docosapentaenoate (n-3,
P
-interaction = 0.021). CMPF level was lower in T2D patients than in the healthy controls (
P
= 0.014) and it was significantly increased in the FO compared with CO group (
P
= 1.17 × 10
−7
). Furthermore, change of CMPF during the intervention was negatively correlated with change of serum triglycerides (
P
= 0.016). In conclusion, furan fatty acid metabolite CMPF was the strongest biomarker of fish oil intake. The association of CMPF with metabolic markers warrants further investigation.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Aged
/ Corn Oil - administration & dosage
/ Diabetes
/ Diabetes Mellitus, Type 2 - blood
/ Docosahexaenoic Acids - blood
/ Eicosapentaenoic Acid - blood
/ Fatty Acids, Omega-3 - administration & dosage
/ Female
/ Fish Oils - administration & dosage
/ Glucose
/ Humanities and Social Sciences
/ Humans
/ Linseed Oil - administration & dosage
/ Male
/ Science
