Journal Article

Posterior reversible encephalopathy syndrome

Fischer, Marlene, Schmutzhard, Erich

2017

Overview

The posterior reversible encephalopathy syndrome (PRES) is a neurological disorder of (sub)acute onset characterized by varied neurological symptoms, which may include headache, impaired visual acuity or visual field deficits, disorders of consciousness, confusion, seizures, and focal neurological deficits. In a majority of patients the clinical presentation includes elevated arterial blood pressure up to hypertensive emergencies. Neuroimaging, in particular magnetic resonance imaging, frequently shows a distinctive parieto-occipital pattern with a symmetric distribution of changes reflecting vasogenic edema. PRES frequently develops in the context of cytotoxic medication, (pre)eclampsia, sepsis, renal disease or autoimmune disorders. The treatment is symptomatic and is determined by the underlying condition. The overall prognosis is favorable, since clinical symptoms as well as imaging lesions are reversible in most patients. However, neurological sequelae including long-term epilepsy may persist in individual cases.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Acuity / Autoimmune diseases / Blood pressure / Consciousness / Cytotoxicity / Edema / Encephalopathy / Epilepsy / Headache / Humans / Kidney transplantation / Magnetic resonance imaging / Medicine / Medicine & Public Health / Neuroimaging / Neurological complications / Neurological diseases / Neurology / Neuroradiology / Neurosciences / Posterior Leukoencephalopathy Syndrome - diagnosis / Posterior Leukoencephalopathy Syndrome - etiology / Posterior Leukoencephalopathy Syndrome - physiopathology / Posterior Leukoencephalopathy Syndrome - therapy / Preeclampsia / Review / Seizures / Sepsis / Visual field