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Metabolic rate of major organs and tissues in young adult South Asian women
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Journal Article
Metabolic rate of major organs and tissues in young adult South Asian women
2019
Overview
Background/Objectives
Major organ-specific and tissue-specific metabolic rate (
K
i
) values were initially estimated using in vivo methods, and values reported by Elia (Energy metabolism: tissue determinants and cellular corollaries, Raven Press, New York, 1992) were subsequently supported by statistical analysis. However, the majority of work to date on this topic has addressed individuals of European descent, whereas population variability in resting energy metabolism has been reported. We aimed to estimate
K
i
values in South Asian females.
Subjects/Methods
This cross-sectional study recruited 70 healthy young women of South Asian ancestry. Brain and organs were measured using magnetic resonance imaging, skeletal muscle mass by dual-energy X-ray absorptiometry, fat mass by the 4-component model, and whole-body resting energy expenditure by indirect calorimetry. Organ and tissue
K
i
values were estimated indirectly using regression analysis through the origin. Preliminary analysis suggested overestimation of heart mass, hence the modeling was repeated with a literature-based 22.5% heart mass reduction.
Results
The pattern of derived
K
i
values across organs and tissues matched that previously estimated in vivo, but the values were systematically lower. However, adjusting for the overestimation of heart mass markedly improved the agreement.
Conclusions
Our results support variability in
K
i
values among organs and tissues, where some are more metabolically “expensive” than others. Initial findings suggesting lower organ/tissue
K
i
values in South Asian women were likely influenced by heart mass estimation bias. The question of potential ethnic variability in organ-specific and tissue-specific energy metabolism requires further investigation.
Publisher
Nature Publishing Group UK,Nature Publishing Group
