Asset Details
Do you wish to reserve the book?
miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma
Do you wish to request the book?
miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma
2018
Overview
Ferroptosis is a regulated form of cell death driven by small molecules or conditions that induce lipid-based reactive oxygen species (ROS) accumulation. This form of iron-dependent cell death is morphologically and genetically distinct from apoptosis, necroptosis, and autophagy. miRNAs are known to play crucial roles in diverse fundamental biological processes. However, to date no study has reported miRNA-mediated regulation of ferroptosis. Here we show that miR-137 negatively regulates ferroptosis by directly targeting glutamine transporter SLC1A5 in melanoma cells. Ectopic expression of miR-137 suppressed SLC1A5, resulting in decreased glutamine uptake and malondialdehyde (MDA) accumulation. Meanwhile, antagomir-mediated inactivation of endogenous miR-137 increased the sensitivity of melanoma cells to erastin- and RSL3-induced ferroptosis. Importantly, knockdown of miR-137 increased the antitumor activity of erastin by enhancing ferroptosis both in vitro and in vivo. Collectively, these data indicate that miR-137 plays a novel and indispensable role in ferroptosis by inhibiting glutaminolysis and suggest a potential therapeutic approach for melanoma.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/109
/ 38/39
/ 42
/ 45
/ 631/80
/ 82
/ 82/1
/ 82/80
/ 96
/ Amino Acid Transport System ASC - antagonists & inhibitors
/ Amino Acid Transport System ASC - genetics
/ Amino Acid Transport System ASC - metabolism
/ Animals
/ Biomedical and Life Sciences
/ Cyclohexylamines - pharmacology
/ Ferrous Compounds - metabolism
/ Humans
/ Lipid Peroxidation - drug effects
/ Malondialdehyde - metabolism
/ Melanoma
/ Mice
/ MicroRNAs - antagonists & inhibitors
/ Minor Histocompatibility Antigens - genetics
/ Minor Histocompatibility Antigens - metabolism
/ miRNA
/ Phenylenediamines - pharmacology
/ Reactive Oxygen Species - metabolism
