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CD28-Negative CD4+and CD8+T Cells in Antiretroviral Therapy—Naive HIV-Infected Adults Enrolled in Adult Clinical Trials Group Studies
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CD28-Negative CD4+and CD8+T Cells in Antiretroviral Therapy—Naive HIV-Infected Adults Enrolled in Adult Clinical Trials Group Studies
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Journal Article
CD28-Negative CD4+and CD8+T Cells in Antiretroviral Therapy—Naive HIV-Infected Adults Enrolled in Adult Clinical Trials Group Studies
2012
Overview
Background. Individuals infected with human immunodeficiency virus (HIV) have higher risk than HIV-negative individuals for diseases associated with aging. T-cell senescence, characterized by expansion of cells lacking the costimulatory molecule CD28, has been hypothesized to mediate these risks. Methods. We measured the percentage of CD28 - CD4 + and CD8 + T cells from HIV-infected treatment-naive adults from 5 Adult Clinical Trials Group (ACTG) antiretroviral therapy (ART) studies and the ALLRT (ACTG Longitudinal Linked Randomized Trials) cohort, and from 48 HIV-negative adults. Pretreatment and 96-week posttreatment %CD28 - cells were assessed using linear regression for associations with age, sex, race/ethnicity, CD4 count, HIV RNA, ART regimen, and hepatitis C virus (HCV) infection. Results. In total, 1291 chronically HIV-infected adults were studied. Pretreatment, lower CD4 count was associated with higher %CD28 - CD4 + and %CD28 - CD8 + cells. For CD8 + cells, younger age and HCV infection were associated with a lower %CD28 - . ART reduced %CD28 - levels at week 96 among virally suppressed individuals. Older age was strongly predictive of higher %CD28 - CD8 + . Compared to HIV-uninfected individuals, HIV-infected individuals maintained significantly higher %CD28 - . Conclusions. Effective ART reduced the proportion of CD28 - T cells. However, levels remained abnormally high and closer to levels in older HIV-uninfected individuals. This finding may inform future research of increased rates of age-associated disease in HIV-infected adults.
Publisher
Oxford University Press
Subject
/ Adult
/ Age
/ Aged
/ AIDS
/ Anti-HIV Agents - administration & dosage
/ Antiretroviral Therapy, Highly Active - methods
/ Biological and medical sciences
/ CD4-Positive T-Lymphocytes - chemistry
/ CD4-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - chemistry
/ CD8-Positive T-Lymphocytes - immunology
/ Female
/ Fundamental and applied biological sciences. Psychology
/ HIV
/ HIV Infections - drug therapy
/ HIV/AIDS
/ Humans
/ Lymphocyte Subsets - chemistry
/ Lymphocyte Subsets - immunology
/ Male
/ RNA
