Journal Article

Predicting depressed and elevated mood symptomatology in bipolar disorder using brain functional connectomes

Villa, Luca M., Goldman, Danielle A., Pittman, Brian, Blumberg, Hilary P., Kim, Jihoon A., Sankar, Anjali, Shen, Xilin, Colic, Lejla, Scheinost, Dustin, Constable, R. Todd

2023

Overview

The study is aimed to identify brain functional connectomes predictive of depressed and elevated mood symptomatology in individuals with bipolar disorder (BD) using the machine learning approach Connectome-based Predictive Modeling (CPM). Functional magnetic resonance imaging data were obtained from 81 adults with BD while they performed an emotion processing task. CPM with 5000 permutations of leave-one-out cross-validation was applied to identify functional connectomes predictive of depressed and elevated mood symptom scores on the Hamilton Depression and Young Mania rating scales. The predictive ability of the identified connectomes was tested in an independent sample of 43 adults with BD. CPM predicted the severity of depressed [concordance between actual and predicted values ( = 0.23, = 0.031) and elevated ( = 0.27, = 0.01) mood. Functional connectivity of left dorsolateral prefrontal cortex and supplementary motor area nodes, with inter- and intra-hemispheric connections to other anterior and posterior cortical, limbic, motor, and cerebellar regions, predicted depressed mood severity. Connectivity of left fusiform and right visual association area nodes with inter- and intra-hemispheric connections to the motor, insular, limbic, and posterior cortices predicted elevated mood severity. These networks were predictive of mood symptomatology in the independent sample ( ⩾ 0.45, = 0.002). This study identified distributed functional connectomes predictive of depressed and elevated mood severity in BD. Connectomes subserving emotional, cognitive, and psychomotor control predicted depressed mood severity, while those subserving emotional and social perceptual functions predicted elevated mood severity. Identification of these connectome networks may help inform the development of targeted treatments for mood symptoms.

• Publisher: Cambridge University Press
• Subject: Ability / Adult / Adults / Affect - physiology / Affective disorders / Bipolar disorder / Bipolar Disorder - diagnostic imaging / Bipolar Disorder - physiopathology / Brain / Brain - diagnostic imaging / Brain - physiopathology / Brain mapping / Cerebellum / Cognitive ability / Connectome - methods / Cortex / Cortex (insular) / Cortex (motor) / Datasets / Depression - diagnostic imaging / Depression - physiopathology / Emotions / Female / Functional connectivity / Functional magnetic resonance imaging / Humans / Machine Learning / Magnetic Resonance Imaging / Male / Mania / Measures / Medical imaging / Mental depression / Mental disorders / Middle Aged / Mood / Neural networks / Neuroimaging / Original / Original Article / Perceptions / Permutations / Prediction models / Predictions / Prefrontal cortex / Severity / Social networks / Supplementary motor area / Symptoms / Treatment methods / Young Adult