Asset Details
Do you wish to reserve the book?
5-ALA vs. fluorescein guided resection for high-grade gliomas: A systematic review and meta-analysis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
5-ALA vs. fluorescein guided resection for high-grade gliomas: A systematic review and meta-analysis
Do you wish to request the book?
5-ALA vs. fluorescein guided resection for high-grade gliomas: A systematic review and meta-analysis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
5-ALA vs. fluorescein guided resection for high-grade gliomas: A systematic review and meta-analysis
2026
Overview
High-grade gliomas (HGGs) are characterized by aggressive biological behavior and dismal prognosis. Both 5-aminolevulinic acid (5-ALA) and other fluorescence-guided surgery (FGS) techniques are used to maximize tumor resection while preserving neurological function. The present study synthesizes current evidence and compares these two approaches in the neurosurgical management of HGGs. A systematic literature search was conducted to identify clinical studies evaluating 5-ALA-guided resection and alternative FGS techniques in patients with HGGs. A total of 41 studies were included, comprising 36 in the qualitative review and 5 in the quantitative meta-analysis. Data were extracted regarding study characteristics, patient demographics, tumor type, median progression-free survival, overall survival (OS), pre- and postoperative Karnofsky Performance Status (KPS ≥70 within 30 days), and postoperative neurological deficits (defined as a newly developed decrease in Glasgow Coma Scale score of ≥2 points, hemiparesis, or aphasia). The pooled population consisted of 732 patients, with 503 (68.7%) undergoing 5-ALA-guided resection and 229 (31.3%) treated with FGS. The mean patient age across studies was 57.9 years. The present meta-analysis demonstrated that 5-ALA-guided surgery was associated with improved outcomes in terms of postoperative neurological deficits, maintenance of KPS ≥70, and OS compared with other FGS techniques. However, the presence of publication bias and the heterogeneity of the underlying data limit the strength of these findings and underscores the need for further high-quality comparative trials before definitive conclusions can be drawn regarding the superiority of one method over the other.
