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Compact RNA editors with small Cas13 proteins
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Journal Article
Compact RNA editors with small Cas13 proteins
2022
Overview
CRISPR–Cas13 systems have been developed for precise RNA editing, and can potentially be used therapeutically when temporary changes are desirable or when DNA editing is challenging. We have identified and characterized an ultrasmall family of Cas13b proteins—Cas13bt—that can mediate mammalian transcript knockdown. We have engineered compact variants of REPAIR and RESCUE RNA editors by functionalizing Cas13bt with adenosine and cytosine deaminase domains, and demonstrated packaging of the editors within a single adeno-associated virus.
Compact Cas13 proteins are used to design RNA editors that fit into a single adeno-associated virus.
Publisher
Nature Publishing Group US,Nature Publishing Group
